N-Boc-2,2-二甲基哌嗪研究

A Study on N-Boc-2,2-dimethyl-piperazine

以乙二胺、2-溴异丁酸乙酯、二碳酸二叔丁酯为原料合成N-Boc-2,2-二甲基哌嗪,对反应温度、反应物配比、催化剂进行考察,经实验确定的最佳合成条件为:以乙二胺∶2-溴异丁酸乙酯为3∶1的反应物配比,在70℃条件下回流得中间体,中间体和二碳酸二叔丁酯经碳酸钾催化反应,最后还原得最终产物。

This paper studies the reaction temperature,ratio of reactants,and catalyst in order to get NBoc-2,2-dimethyl-piperazine,a synthesis of ethylenediamine,ethyl 2-bromoisobutyrate,and di-tert-butyl dicarbonate.Experiment results suggest that the optimal condition is：first,using ethylenediamine and ethyl 2-bromoisobutyrate with a ratio of 3∶1to get intermediate product under 70℃;and then using the potassium carbonate to catalyze the intermediate product to get the final product.