杭州地区体检人群乙型肝炎病毒血清学标志物分布特征

Distribution characteristics of hepatitis B virus serological markers in health examination population in Hangzhou district

目的：探讨杭州地区体检人群乙型肝炎病毒血清学标志物（HBV-M）的模式分布特征,为制定针对性预防控制措施提供依据。方法：采用化学发光免疫分析法对2014年杭州地区8 707例体检人群的血液标本进行HBV-M检测。结果：在8 707例体检人员标本中,共检测出13种HBV-M的血清学模式。HBsAb单（＋）为主要模式,占30.48%;其次是全部阴性（-）模式和HBsAb（＋）HBcAb（＋）模式,分别占22.64%和15.09%。其余10种模式所占比例在0.02%~12.05%。1 032例标本为HBsAg反应性,体检人群总体HBsAg血清学反应性率为11.83%。所有HBsAb反应性体检者的HBsAb水平分为3个范围：10~100mIU/mL（48.54%）,100~1 000mIU/mL（41.14%）,和〉1 000mIU/ml（10.32%）。结论：杭州地区体检人群HBsAg携带率和HBsAb反应性率相对较高,而HBV-M全部阴性模式相对较低。3种主要的血清学模式分布特征与年龄和性别有关。针对HBV-M阴性的易感人群,应及时开展乙型肝炎病毒疫苗接种,从而降低HBV感染风险。

Objective：To investigate the distribution characteristics of serological patterns of hepatitis B Markers（HBV-M）in a health examination population of Hangzhou district,and provide evidence for the targeted prevention and control measures.Method：The HBV-M in 8707 blood specimens of health examination population in Hangzhou district in 2014 were tested by chemiluminescence immunoassays.Result：Among 8707 blood samples,13 serological patterns of hepatitis B were determined.The dominant pattern was＇ HBsAb（＋）alone＇（30.48%）,followed by＇negative pattern＇（22.64%）and＇HBsAb（＋）HBcAb（＋）pattern＇（15.09%）.The rates of the other 10 patterns ranged from 12.05%to 0.02%.Of 1030 HBsAg reactive samples,the overall rate of HBsAg seroreactivity was 11.83%.The HBsAb levels were grouped into 3concentration ranges（10-100mIU/mL,100-1 000mIU/mL,and〉1000mIU/mL）for all HBsAb reactive subjects（48.54%,41.14%and 10.32%,respectively）.Conclusion：A relatively high HBsAg carrier and HBsAb reactive rate and a low negative pattern are present in a health examination population in Hangzhou district.The distribution characteristics of three dominant serological patterns may be associated with age and gender.For susceptible population of HBV-M negative,it should be vaccinated promptly,thereby reducing the risk of HBV infection.