国产CEFTAZIDIME的微生物学评价

BACTEPJOLOGICAL EVOLUTION OF CEFTAZIDINE

本文报道国产Ceftazidime对临床分离681株致病菌进行体内外抗菌活性研究,并与头孢噻肟、头孢三嗪、Moxalactam、头孢哌酮、Cefsulodin、头孢孟多、头孢唑啉、头孢噻吩、哌拉西林、替卡西林、庆大霉素及丁胺卡那霉素的抗菌作用进行比较。实验证明Ceftazidime与第三代头孢菌素的抗菌活性相似,其独特之处是抗绿脓杆菌活力强,对400株绿脓杆菌的MIC_(50)、MIC_(90)及MIC_(Gm)分别为1.6、3.2及1.57μg/ml。对121株多种耐药绿脓杆菌,有98.4％的菌株敏感。对小鼠感染绿脓杆菌有明显治疗效果,其ED_(50)为3.09～4.14mg/kg。结果表明:Ceftazidime抗绿脓杆菌作用极强,显著优于其他抗生素,为临床治疗绿脓杆菌感染的重症患者提供了一个新抗生素。

The in vitro and in vivo of home-made Ceftazidime bacteriological evolution was attempted by using on agar dilution technique against 400 strains of P. aeruginosa and 281 strains of 19 various kinds of bacteria which were isolated clinically. The 12 antibiotics were simultaneously compared. The results showed that Ceftazidirae had a broad antibacterial spectrum and other third generation cephalosporias were similar in activity against enteric bacilli.However,the activity which against P, aeruginosa showed its excellent action. Its MIC50, MIC90 and MIC GM values were 1.6μg/ml, 3.2μg/ml and 1.57 μg/ml respectively.At the level of 3.2μg/ml.Ceftazidime markedly inhibited 94%of P. aeruginosa strains tested, while the others, Cefsulodin 82%, Piperacillin and Cefoperazone 40-50%, Gentamicin and Amikacin 18-20% respectively. But Cefotaxime, Ceftriasone, Moxalactam and Ticacillin only gave 1-6%, inhibition. In the case of 121 multi-resistant strains of P. aeruginosa tested Ceftazidime also showed the highest activity than the other 9 antibiotics.98.4%of the 121 Multi-resistant strains tested was sensitive to Ce ftazidime.but all of the strains were resistant to Gentamicin.Ticacillin and Amikacin. In mice infected with P. aeruginosa.the therapeutic efficacies of Ceftazidime were higher than,that of Gentamicin.Piperacillin,Cefoperazone and Moxalactam.