乌灵胶囊、尼莫地平联合氟西汀治疗脑卒中后抑郁障碍的疗效观察

The Efficacy of Wuling Capsule,Nimodipine combined with Fluoxetine Treated for Post-stroke Depression

目的:探讨乌灵胶囊、尼莫地平联合氟西汀治疗脑卒中后抑郁障碍(PSD)的疗效观察。方法:将普宁市人民医院2012年1月-2014年6月收治的105例PSD患者按照入院先后顺序分为氟西汀组,尼莫地平+氟西汀组,乌灵胶囊+尼莫地平+氟西汀组(以下简称联合组),每组各35例,三组患者均继续按常规的神经营养剂、脑血管病药物及康复治疗,氟西汀组采用口服氟西汀治疗,尼莫地平+氟西汀组采用氟西汀联合尼莫地平口服治疗,联合组采用乌灵胶囊、尼莫地平联合氟西汀口服治疗。比较三组患者治疗前后的汉密顿抑郁量表(HAMD)、简易智力状态检查量表(MMSE)及美国国立卫生研究院卒中量表(NIHSS)评分情况。结果:尼莫地平+氟西汀组患者治疗后第4周、第6周及第8周的MMSE评分均高于氟西汀组,治疗后第4周、第6周及第8周的HAMD、NIHSS评分均低于氟西汀组治疗方案,比较差异有统计学意义(P<0.05);联合组患者治疗后第2周、第4周、第6周及第8周的MMSE评分均显著高于氟西汀组比较差异有统计学意义(P<0.001);联合组患者治疗后第2周、第4周、第6周及第8周的HAMD、NIHSS评分均显著低于氟西汀组,比较差异有统计学意义(P<0.05);联合组患者治疗后第6周及第8周的MMSE评分均显著高于尼莫地平+氟西汀组,HAMD、NIHSS评分均显著低于尼莫地平+氟西汀组比较差异有统计学意义(P<0.05)。结论:乌灵胶囊,尼莫地平联合氟西汀治疗PSD效果更为理想,可更好的降低PSD患者的抑郁状况,改善神经功能。

Objective：To explore the efficacy of Wuling Capsule,Nimodipine combined with fluoxetine treated for Post-stroke depression.Method：105 patients with Post-stroke depression from Puning City People＇s Hospital from January 2012 to June 2014 were randomly divided into fluoxetine group,Nimodipine ＋ fluoxetine group,Wuling Capsule ＋ Nimodipine ＋ fluoxetine group（hereinafter referred to as combined group）,35 cases in each group,patients were treated with routinely continue neurotrophic agent,cerebrovascular disease and drug rehabilitation treatment,Fluoxetine group was treated with oral Fluoxetine,Nimodipine ＋ fluoxetine group was treated with fluoxetine combined Nimodipine oral,the treatment group was Wuling joint capsules,oral Nimodipine therapy and fluoxetine,the Joint Group was treated with Wuling Capsule,Nimodipine combined with fluoxetine.The HAMD score,Mini-Mental State Examination（MMSE） and the US National Institutes of Health Stroke Scale（NIHSS） score was used to evaluate the three groups.Result：The MMSE scores of the Nimodipine ＋ fluoxetine group patients after the first four weeks,6 weeks and 8 weeks was significantly higher than that of the fluoxetine group.The HAMD,NIHSS scores of the joint group after the first four weeks,6 weeks and 8 weeks was significantly lower than that of the fluoxetine group（P〈0. 05）.The MMSE scores of the joint group patients after the first 2 weeks,4 weeks,6 weeks and 8 weeks was significantly higher than that of the fluoxetine group,the HAMD,NIHSS scores of the joint group after the first four weeks,6 weeks and 8 weeks was significantly lower than that of the fluoxetine group（P〈0. 05）.The MMSE score of the joint group after the first four weeks,6 weeks and 8 weeks was significantly higher than that of the fluoxetine combined Nimodipine group（P〈0. 05）.The HAMD,NIHSS scores of the joint group after the first 6 weeks and 8 weeks was significantly lower than that of the fluoxetine combined Nimodipine group（P〈0. 05）.Conclusion：Wuling Capsule,Nimodipine plus fluoxetine treated with PSD has better efficacy,that could improved the Neurological function.