糖尿病患者报告结局、生命质量与基因多态性关系的初步探讨

Preliminary study on relationships between gene polymorphism and patients-reported outcomes, quality of life in patients with diabetes mellitus

目的初步探讨基因多态性与糖尿病患者报告结局、生命质量之间的关系。方法采取文献综述、专家咨询和核心小组讨论等方法寻找影响疾病发生发展、影响个体情绪行为等方面的基因,分析这些基因影响患者报告结局、生命质量的可能机制。结果影响糖尿病发生和发展的基因有KCNJ11、TCF7L2、SLC30A8;影响个人情绪行为的基因有ACE、多巴胺D4受体基因、5-羟色胺转运体基因。结论 KCNJ11、TCF7L2、SLC30A8、ACE、多巴胺D4受体基因、5-羟色胺转运体基因可能与患者报告结局或生命质量有关,值得进一步探讨。

Objective To investigate preliminarily relationships between gene polymorphism and patients reportedoutcomes, quality of life in patients with diabetes mellitus. Methods Through the literatures review, experts consulting and core group discussions to find out genes which influence disease, progression and have effects on the individuals＇ emotional behaviors, and to compare PRO/QOL by genotype. Results The genes KCNJ11, TCF7L2 and SLC30A8 influence disease, progression; the genes ACE, DRD4, 5-HTT have effects on the individual＇s emotional behaviors. Conclusion The genes KCNJ11, TCF7L2, SLC30A8, ACE, DRD4, 5-HTT may influence QOL/PRO, and need to be studied further.