早期初诊帕金森病患者非运动症状的研究

Study of non-motor symptoms in early stage newly diagnosed Parkinson's disease

目的探讨早期帕金森病(PD)患者不同年龄分组、不同临床亚型非运动症状(NMS)的特点。方法收集门诊首次就诊且发病在1年内的早期PD患者96例和正常对照者102例,调查临床资料及相关量表并进行比较。结果 91例(93.83%)患者至少出现1项NMS,常见症状依次为近记忆力下降(70.83%,68例)、便秘(48.96%,47例)、注意力下降(47.92%,46例),比例均高于对照组(均P<0.01)。年龄≤60岁较年龄>60岁感焦虑害怕或恐慌的发生率明显升高(P<0.01);强直型尿急的发生率明显高于震颤型(P<0.01)。结论早期PD患者非运动症状复杂多样。不同年龄组及不同临床亚型NMS的表现也有所差异。

Objective To investigate the clinical characteristics of non-motor symptoms （ NMS） in early stage newly diagnosed Parkinson ＇s disease （ PD） patients in different age group and different subtypes .Methods Total 96 newly diagnosed PD patients without taking any drugs and 102 normal controls were collected in outpatient visits , and their clinic information and related scales were evaluated and compared .Results Ninety-one（93.83%） PD patients had at least one NMS, common symptoms were, in order, recent memory （70.83%,68 cases）、constipation （48.96%,47 cases）、attention dysfunction （47.92%,46 cases）, and they were significantly higher than PD group （all P〈0.01）.The incidence of anxiety and panic in patients≤60 years old was significantly higher than that in patients≤60 years old （P〈0.01）.The incidence of urgency in rigidity type was significantly higher than in tremor type（P〈0.01）.Conclusions NMS in patients with newly diagnosed PD are complex and diverse .The performance in different age groups and different clinical subtypes are also different .