期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞凋亡的信号通路 被引量：16

The Signal Pathway of Apoptosis
下载PDF
导出
摘要 细胞凋亡是细胞程序性死亡的一种方式,与自噬和坏死有明显的区别。细胞凋亡的信号途径比较复杂,在凋亡诱导因子的刺激下经历不同的信号途径。本文就细胞凋亡的三条信号通路——线粒体途径、内质网途径和死亡受体途径做一综述,以便为人们进一步了解细胞凋亡发生的机制,从而对癌症及其他一些相关疾病的治疗奠定基础。 Apoptosis is a process of programmed cell death which distinguishes from autophagy and necrosis. The signal pathways of apoptosis are complex and different under apoptosis induced factor stimulating. Three kinds of signal pathways of apoptosis including Mitochondrial pathway, Endoplasmic Reticulum pathway and Death Receptor pathway were summarized in this review in order to make people further comprehend the mechanism of apoptosis,so that it should make a basis for us all to treat cancer and other related diseases.
作者 谢昆 李兴权
机构地区 红河学院生命科学与技术学院
出处 《山东农业大学学报（自然科学版）》 CSCD 2015年第4期514-518,共5页 Journal of Shandong Agricultural University：Natural Science Edition
基金 云南省科技厅应用基础研究面上项目(2010ZC151)
关键词 细胞凋亡 信号通路 线粒体途径 内质网途径 死亡受体途径 Apoptosis signal pathway Mitochondrial pathway Endoplasmic Reticulum pathway Death Receptor pathway
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献41

  • 1Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death[J]. Physiological reviews, 1972,87(1):99-163.
  • 2Kerr JF. History of the events leading to the formulation of the apoptosis concept[J]. Toxicology, 2002,181:471-474.
  • 3Paweletz N. Walther Flemming: Pioneer of mitosis research[J]. Nature Reviews Molecular Cell Biology, 2001,2(1):72-76.
  • 4Elmore S. Apoptosis: a review of programmed cell death[J]. Toxicol Pathol, 2007,35(4):495-516.
  • 5Min F, Dong WX. The mitochondrial pathways of apoptosis[J]. Journal of Beijing Medical University, 2002,1:157-183.
  • 6Hirsch T, Marchetti P, Susin SA, et al. The apoptosis-necrosis paradox. Apoptogenic proteases activated aftermitochondrial permeability transition determine the mode of cell death[J]. Oncogene , 1997,15(13):1573.
  • 7Zeiss C. The apoptosis-necrosis continuum: insights from genetically altered mice[J]. Veterinary Pathology Online, 2003, 40(5):481-495.
  • 8Ghavami S, Hashemi M, Ande SR, et al. Apoptosis and cancer: mutations within caspase genes[J]. J Med Genet, 2009,46(8):497-510.
  • 9Desagher S, Martinou J-C. Mitochondria as the central control point of apoptosis[J]. Trends Cell Biol, 2000,10(9):369.
  • 10Autret A, Martin SJ. Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis[J].Mol Cell,2009, 36(3):355-363.

二级参考文献22

  • 1Walter L,Hajnoczky G.Mitochondria and endoplasmic reticulum:the lethal interorganelle cross-talk[J].J Bioenerg Biomembr,2005,37(3):191-206.
  • 2Rizzuto R,Pinton P,Ferrari D,et al.Calcium and apoptosis:facts and hypotheses[J].Oncogene,2003,22 (53):8619-8627.
  • 3Demaurex N,Distelhorst C.Apoptosis-the calcium connection[J].Science,2003,300(5616):65-67.
  • 4Orrenius S,Zhivotovsky B,Nicotera P.Regulation of cell death:the calcium-apoptosis link[J].Nat Rev Mol Cell Biol,2003,4 (7):552-565.
  • 5Kim MJ,Jo DG,Hong GS.Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death[J].Proc Natl Acad Sci USA,2002,99(15):9870-9875.
  • 6Szabadkai G,Simoni AM,Chami M,et al.Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca^2+ waves and protects against Ca2 + -mediated apoptosis[J].Mol Cell,2004,16(1):59-68.
  • 7Pan Z,Damron D,Nieminen AL,et al.Depletion of intracellular Ca^2+ by caffeine and ryanodine induces apoptosis of chinese hamster ovary cells transfected with ryanodine receptor[J].J Biol Chem,2000,275(26):19978-19984.
  • 8Oyadomari S,Takeda K,Takiguchi M,et al.Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway[J].Proc Natl Acad Sci USA,2001,98(19):10845-10850.
  • 9Verkhratsky A,Toescu EC.Endoplasmic reticulum Ca^2+ homeostasis and neuronal death[J].J Cell Mol Med,2003,7(4):351-361.
  • 10Bardo S,Cavazzini MG,Emptage N.The role of the endoplasmic reticulum Ca^2+ store in the plasticity of central neurons[J].Trends Pharmacol Sci,2006,27(2):78-84.

共引文献9

同被引文献216

引证文献16

二级引证文献50

山东农业大学学报（自然科学版）
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部