微囊栓制剂降低尼美舒利豚鼠肝毒性的实验研究

The preliminary inquiry of nimesulide microcapsule suppository reduce Guinea pig liver toxicity

目的考察尼美舒利微囊栓降低尼美舒利对肝脏毒性的影响作用。方法豚鼠随机分为尼美舒利普通栓组和尼美舒利微囊栓组,分别直肠给相应的栓剂。15天后处死并检测豚鼠肝脏中丙氨酸氨基转移酶和天冬氨酸氨基转移酶含量,同时观察其肝组织的病理变化。结果尼美舒利微囊栓组与尼美舒利普通栓组相比,其丙氨酸氨基转移酶和天冬氨酸氨基转移酶含量均明显降低,分别为(163.159 1±0.748 6)、(77.525 1±0.679 4)U·L-1,P<0.05。豚鼠肝脏病理切片显示微囊栓组豚鼠肝损伤程度明显低于普通栓组豚鼠。结论微囊栓能降低尼美舒利的肝脏毒性。

Objective To explore the influence of Nimesulide Microcapsule Suppository on reducing the liver toxicity of nimesulide. Methods Guinea pig were randomly divided into nimesulide ordinary suppository group and nimesulide microcapsule suppository group. Each group respectively with rectal administration to use the corresponding suppository. After15 days,Guinea pig were sacrificed and liver tissue ALT and AST activity observed path-ological changes in liver tissue. Results The nimesutide microcapsule suppository group of guinea pig was compared with the ordinary suppository group of guinea pig whose aspartate aminotransferase,alanine aminotransferase were significantly decreased,respectively（ 163. 159 1 ± 0. 748 6）,（ 77. 525 1 ± 0. 679 4） U·L^-1,P〈0. 05; Microscopic observation of guinea pig liver biopsy,liver damage microcapsule suppository group of guinea pig was significantly lower extent. Conclusion Microcapsule suppository reduced liver toxicity nimesulide.