心肌标志物在急性心肌梗死检测中的临床意义

Clinical significance in detecting myocardial markers in acute myocardial infarction

目的探讨肌钙蛋白I(cTnI)、肌红蛋白(MYO)和肌酸激酶同工酶(CK-MB)在急性心肌梗死(AMI)中的早期诊断,比较它们在AMI诊断中的应用意义。方法采用化学发光法对126例AMI患者及82例非心肌梗死组进行cTnI、MYO和CKMB检测,对其结果进行比较分析。结果 cTnI、MYO、CK-MB出现时间及达到峰值的时间都不同,AMI患者cTnI、MYO和CKMB联合检测的敏感度、特异度、阴性预测值、阳性预测值高于单项检测。结论 cTnI、MYO和CK-MB的联合检测有助于早期确诊AMI。

Objective To explore the Troponin I（cTnI） ,myoglobin（MYO） and creatine kinase isoenzyme（CK‐MB） in early di‐agnosis of acute myocardial infarction（AMI） ,and compare their significance in the diagnosis of AMI .Methods used chemilumines‐cence method in 126 patients with AMI and 82 cases of myocardial infarction group to test cTnI ,MYO and CK‐MB ,the results were compared .Results The cTnI ,MYO ,CK‐MB quality appear time and peak time was different ,in patients with acute myocardial in‐farction（cTnI ,MYO and CK‐MB joint detection sensitivity ,specificity ,negative predictive value ,positive predictive value was higher than single test .Conclusion cTnI ,MYO and CK‐MB joint detection is helpful to early diagnosis of AMI .