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婴幼儿血管瘤的诊断与治疗 被引量:14

Diagnosis and treatment of infantile hemangiomas: current trends
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摘要 婴幼儿血管瘤(IH)是儿童最常见的良性肿瘤,60%以上发生于头颈部,其大小、形态、生长情况、消退后的残余病变和对治疗的反应程度等个体差异很大。根据病史和临床表现,一般均能明确诊断,必要时可做彩色超声和(或)磁共振辅助诊断。血管瘤的治疗手段包括药物治疗、激光治疗和手术治疗3大手段,需根据部位、大小、类型、分期等选择合适的治疗方法。普萘洛尔因疗效、耐受性和安全性均优于糖皮质激素,现已成为首选的一线治疗药物,但其远期影响有待观察和评价。IH的最快速增殖期约在出生后2个月完成,如需全身治疗,最好在3个月前开始。治疗的目的是控制血管瘤生长,加速消退,减少后遗症。 Infantile hemangiomas(IHs) are the most common benign vascular neoplasms in infancy and children. More than 60% of them occur in the head and neck area. Significant differences exit between individuals in tumour size, shape,growth pattern, sequela after involution and treatment response. Generally, diagnosis can be made according to the typical natural history and clinical features, colour Doppler ultrasonography and/or MRI is considered when necessary. IHs can be treated using pharmacotherapy, laser therapy and surgery. Selection of appropriate treatment modalities is based on the specific location, extent, types and phases. Propranolol has replaced corticosteroids as preferred first-line therapy for the management of IHs due to its excellent efficacy, good tolerability and safety, but the long-term impact needs to be evaluated. Initiation of systemic therapies if needed should ideally be initiated prior to 3 months of age because most IHs reach the fast proliferation phase at 2 months of age. The purpose for intervention includes control of tumour growth,promoting regression and reducing sequelae.
出处 《中国口腔颌面外科杂志》 CAS 2015年第4期289-296,共8页 China Journal of Oral and Maxillofacial Surgery
基金 国家自然科学基金(81470755) 中国博士后基金(2013)~~
关键词 婴幼儿血管瘤 普萘洛尔 Β受体阻滞剂 Infantile hemangiomas Propranolol β-blocker
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参考文献21

  • 1Lraute-Labreze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy [J]. N Engl J Med, 2008,358(24):2649 - 2651.
  • 2Drolet BA, Frommelt PC, Chamlin SL, et al. Initiation and use of propranolol for infantile hemangioma: report of a consensus conference [J]. Pediatrics, 2013,131(1):128-140.
  • 3Wojcicki P, Wojcicka K. Epidemiology, diagnostics and treatment of vascular tumours and malformations [J]. Adv Clin Exp Med, 2014,23(3):475-484.
  • 4Kanada KN, Merin MR, Munden A, et al. A prospective study of cutaneous findings in newborns in the United States: correlation with race, ethnicity, and gestational status using updated classification and nomenclature[J]. J Pediatr,2012,161(2):240-245.
  • 5Drolet BA, Swanson EA, Frieden IJ. Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants [J]. J Pediatr, 2008,153(5):712 - 715, 715.e1.
  • 6王琳,米双利,陈杰,刘芳,李迎春,郭彩虹,张勇,范钦颖.孕期暴露因素与新生儿血管瘤发生的关联性研究[J].中国药物警戒,2012,9(3):140-143. 被引量:8
  • 7Haggstrom AN, Lammer EJ, Schneider RA, et al. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development [J]. Pediatrics, 2006,117(3): 698-703.
  • 8Haggstrom AN, Drolet BA, Baselga E, et al. Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment [J]. Pediatrics, 2006,118(3):882-887.
  • 9Charalin SL, Haggstrom AN, Drolet BA, et al. Muhicenter prospective study of ulcerated hemangiomas [J]. J Pediatr, 2007,151 (6):684-689.
  • 10Glick ZR, Frieden LJ, Garzon MC, et al. Diffuse neonatal hemangiomatosis: an evidence-based review of case reports in the literature [J]. J Am Acad Dermatol, 2012,67(5):898-903.

二级参考文献24

  • 1Bruekner AL,Frieden IJ.Hemangiomas of infancy[J].Am AcadDermatlol,2003,48(4):477-493.
  • 2北京市卫生局信息网.北京市新生儿出生缺陷发生情况[EB/OL].http://www.bjhb.gov.cn/kzjzproject/xse/xseqx.html.
  • 3中国出生缺陷监测中心.中国出生缺陷监测工作手册[R].1995:57-77.
  • 4Boye E,Yu Y,Paranya G,et al.Clonality and altered behavior ofendothelial cells from hemangiomas[J].J Clin Invest,2001,107:745-752.
  • 5Berg JN,Walter JW,Thisanagayam U,et al.Evidence for loss ofheterozygosity of 5q in sporadic haemangiomas:are somatic mut-ations involved in haemangioma formation[J].J Clin Pathol,2001,54:249-252.
  • 6Walter JW,Blei F,Anderson JL,et al.Genetic mapping of a novelfamilial form of infantile hemangioma[J].Am J Med Genet,1999,82:77-83.
  • 7Dickison P,Christou E,Wargon O.A prospective study of infan-tile hemangiomas with a focus on incidence and risk factors[J].PediatrDermatol,2011,28(6):663-669.
  • 8Haggstrom AN,Drolet BA,Baselga E,et al.Prospective study ofinfantile hemangiomas:demographic,prenatal,and perinatalcharacteristics[J].J Pediatr,2007,150:291-294.
  • 9Chang EI,Chang EI,Thangarajah H,et al.Hypoxia,hormones,and endothelial progenitor cells in hemangioma[J].Lymphat Res Biol,2007,5:237-243.
  • 10Rothman KJ,Moore LL,Singer MR,et al.Teratogenicity of highvitamin A intake.N Engl J Med,1995,333(21):1369-1373.

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