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Influence of gut bacteria on development and progression of non-alcoholic fatty liver disease 被引量:6

Influence of gut bacteria on development and progression of non-alcoholic fatty liver disease
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摘要 The intestine of the human contains a dynamic population of microbes that have a symbiotic relationship with the host. In addition, there is an effect of the intestinal microbiota on metabolism and digestion. Non-alcoholic fatty liver disease(NAFLD) is a common cause worldwideof hepatic pathology and is thought to be the hepatic manifestation of the metabolic syndrome. In this review we examine the effect of the human microbiome on the components and pathogenesis of the metabolic syndrome. We are now on the threshold of therapeutic interventions on the human microbiome in order to effect human disease including NAFLD. The intestine of the human contains a dynamic populationof microbes that have a symbiotic relationship withthe host. In addition, there is an effect of the intestinalmicrobiota on metabolism and digestion. Non-alcoholicfatty liver disease (NAFLD) is a common cause worldwideof hepatic pathology and is thought to be the hepaticmanifestation of the metabolic syndrome. In this reviewwe examine the effect of the human microbiome onthe components and pathogenesis of the metabolicsyndrome. We are now on the threshold of therapeuticinterventions on the human microbiome in order to effecthuman disease including NAFLD.
出处 《World Journal of Hepatology》 CAS 2015年第12期1679-1684,共6页 世界肝病学杂志(英文版)(电子版)
关键词 MICROBIOME METABOLIC SYNDROME Stooltransplantation Non-alcoholic FATTY liver disease Microbiome Metabolic syndrome Stool transplantation Non-alcoholic fatty liver disease
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  • 1Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, HortonJD, Cohen JC, Grundy SM, Hobbs HH. Prevalence of hepaticsteatosis in an urban population in the United States: impact ofethnicity. Hepatology 2004; 40: 1387-1395 [PMID: 15565570DOI: 10.1002/hep.20466].
  • 2Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, ContrerasM, Landt CL, Harrison SA. Prevalence of nonalcoholic fatty liverdisease and nonalcoholic steatohepatitis among a largely middleagedpopulation utilizing ultrasound and liver biopsy: a prospectivestudy. Gastroenterology 2011; 140: 124-131 [PMID: 20858492DOI: 10.1053/j.gastro.2010.09.038].
  • 3Caldwell S, Argo C. The natural history of non-alcoholic fattyliver disease. Dig Dis 2010; 28: 162-168 [PMID: 20460906].
  • 4Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, JiaW, Pettersson S. Host-gut microbiota metabolic interactions.Science 2012; 336: 1262-1267 [PMID: 22674330 DOI: 10.1126/science.1223813].
  • 5Floch MH. The power of poop: probiotics and fecal microbialtransplant. J Clin Gastroenterol 2012; 46: 625-626 [PMID:22874805 DOI: 10.1097/MCG.0b013e3182667a93].
  • 6Ley RE, Lozupone CA, Hamady M, Knight R, Gordon JI. Worldswithin worlds: evolution of the vertebrate gut microbiota. Nat RevMicrobiol 2008; 6: 776-788 [PMID: 18794915 DOI: 10.1038/nrmicro1978].
  • 7Zoetendal EG, Akkermans AD, De Vos WM. Temperaturegradient gel electrophoresis analysis of 16S rRNA from humanfecal samples reveals stable and host-specific communities ofactive bacteria. Appl Environ Microbiol 1998; 64: 3854-3859[PMID: 9758810].
  • 8Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, GordonJI. The effect of diet on the human gut microbiome: a metagenomicanalysis in humanized gnotobiotic mice. Sci Transl Med 2009; 1:6ra14 [PMID: 20368178 DOI: 10.1126/scitranslmed.3000322].
  • 9Bowey E, Adlercreutz H, Rowland I. Metabolism of isoflavonesand lignans by the gut microflora: a study in germ-free and humanflora associated rats. Food Chem Toxicol 2003; 41: 631-636 [PMID:12659715].
  • 10Gérard P, Béguet F, Lepercq P, Rigottier-Gois L, Rochet V,Andrieux C, Juste C. Gnotobiotic rats harboring human intestinalmicrobiota as a model for studying cholesterol-to-coprostanolconversion. FEMS Microbiol Ecol 2004; 47: 337-343 [PMID:19712322 DOI: 10.1016/S0168-6496(03)00285-X].

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