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乳腺癌TopoⅡα、C-MYC基因检测与Ki-67表达的研究 被引量:2

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摘要 目的探讨基底细胞样乳腺癌(BLBC)和非基底细胞样乳腺癌(NBLBC)癌组织中TopoⅡα、C-MYC基因扩增与Ki-67表达的关系。方法选取2010年2月~2014年8月在该院临床病理诊断中心经石蜡包埋的BLBC及NBLBC癌组织各100例,同时选取100例周围正常的乳腺组织为对照。结果 TopoⅡα与C-MYC基因改变类型主要为扩增与缺失,对照组无TopoⅡα、C-MYC和Ki-67表达。100例BLBC病理组织中,TopoⅡα与C-MYC基因扩增分别为43例和51例,缺失分别为57例49例;Ki-67阴性24例、阳性76例;Spearman等级相关分析显示,TopoⅡα、C-MYC基因扩增与Ki-67表达相关(P〈0.05)。100例NBLBC病理组织中,TopoⅡα与C-MYC基因扩增分别为扩增34例和43例,缺失66例和57例;Ki-67阴性16例、阳性84例;Spearman等级相关分析显示,TopoⅡα、C-MYC基因扩增与Ki-67表达相关(P〈0.05),TopoⅡα与C-MYC基因扩增呈正相关关系(P〈0.05)。与NBLBC比,BLBC的TopoⅡα与C-MYC基因扩增略多。结论 TopoⅡα、CMYC基因扩增与Ki-67相关,BLBC癌组织的TopoⅡα、C-MYC基因扩增多于NBLBC癌组织,TopoⅡα与C-MYC基因扩增可能参与乳腺癌的发生发展过程。
出处 《中国妇幼保健》 CAS 2015年第24期4210-4213,共4页 Maternal and Child Health Care of China
基金 黑龙江省卫生计生委科研课题〔2014-187〕 齐齐哈尔医学院院内基金资助项目〔QY20152-04〕
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同被引文献29

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