小剂量奥氮平防治化疗后恶心呕吐的临床观察

The clinical observation of small dose of olanzapine to prevent and control nausea and vomiting after chemotherapy

目的:评估小剂量奥氮平防治化疗所致恶心呕吐(CINV)的疗效。方法:80例需化疗患者随机分为两组,研究组(40例)和对照组(40例)。两组在化疗前给予静脉注射托烷司琼5mg,地塞米松5mg,研究组于化疗当天开始给予口服奥氮平5mg/d,观察两组化疗后恶心呕吐情况。结果:研究组和对照组急性呕吐发生率分别为22.5%(9/40)和47.5%(19/40),差异具有统计学意义(P<0.05),迟发型恶心呕吐的发生率分别为17.5%(7/40)和37.5(15/40),差异具有统计学意义(P<0.05)。结论:小剂量奥氮平(5mg/d)对防治化疗后恶心呕吐疗效明显。

Objective：To evaluate the curative effect of low -dose olanzapine in prevention and treatment of chemotherapy induced nausea and vomiting.Methods：80 cases of chemotherapy patients were randomly divided into two groups,the test group （40 cases）,control group （40 cases）.Before chemotherapy the test group and the control group given intravenously navoban tropisetron 5 mg and dexamethasone 5 mg,the test group were given olanzapine 5 mg daily started on the day of chemotherapy.Then two groups of nausea and vomiting after chemotherapy were ob-served.Results：The test group and the control group acute vomiting incidence was 22.5%（9 /40）and 47.5%（19 /40）,with statistical significance （P 〈0.05）,late onset incidence of nausea and vomiting were 17.5%（7 /40）and 37.5（15 /40）,with statistical significance （P 〈0.05）.Conclusion：Small dose of olanzapine （5mg/d）for preven-tion of nausea and vomiting after chemotherapy curative effect is obvious.