中枢神经感染患者脑脊液免疫指标探讨

Discussion on immune indexs in cerebrospinal fluid with infection diseases of central nervous system

目的探讨分析中枢神经感染患者脑脊液免疫指标检测意义。方法选取我院2013年1∽12月间收治的60例中枢神经感染患者,其中20例病毒性脑膜炎患者作为A组,20例结核性脑膜炎患者作为B组,20例化脓性脑膜炎患者作为C组,另选取20例非中枢神经系统感染者作为D组。以免疫比浊法对各组脑脊液CRP含量进行测定,以双抗体夹心法测、酶联免疫法对各组脑脊液NSE、IFN-γ含量进行测定。结果与D组比较,C组、B组CRP含量上升,差异有统计学意义（P〈0.05）;与D组比较,各组NSE含量上升,A组〉C组〉B组差异有统计学意义（P〈0.05）;与D组比较,B组、A组IFN-γ含量上升,差异有统计学意义（P〈0.05）。结论检测脑脊液免疫指标CRP、NSE、IFN-γ的含量变化,有助于中枢神经感染的诊断鉴别。

Objective To investigate the significance of cerebrospinal fluid discussion on immune indexes in atients with CNS infection. Methods The 60 cases of CNS infection patients were selected admitted in our hospital in January 2013 to December 2013,including 20 cases of viral meningitis patients were group A,20 cases of patients with tuberculous meningitis were group B,20 cases of patients with purulent meningitis as group C,the other 20 cases were selected infection of non central nervous system as D group.With immune turbidmetry on the content of CRP in each group were measured in cerebrospinal fluid,double antibody sandwich method,ELISA method was used to determine the cerebrospinal fluid NSE,IFN-γ.ResultsThe CRP content of C group and B group were increased,compared with D group（P〈0.05）,the difference was statistically significant.The NSE content were increased,A group was most,and the C group was more than the B group,compared with D group（P〈0.05）,the difference was statistically significant;Compared with D group,IFN- γ content of B group and A group were increased（P〈0.05）,statistical significance.ConclusionThe detection of changes in cerebrospinal fluid and immune indexes CRP,NSE,IFN-γ,is helpful in the differential diagnosis of central nervous infection.