摘要
酒精性肝病(alcoholic liver disease,ALD)是指长期过量饮酒导致的肝脏疾病,严重影响人们的生命健康。其发病机制一般认为与酒精及其代谢产物的毒性作用、氧化应激、免疫介导、细胞因子、细胞凋亡、内毒素和病毒等因素有关。中药具有多靶点、多环节治疗的特点,在降低血脂、改善肝脂肪性变、防止肝硬化等方面有较好的疗效。多种中药有效成分对酒精性肝损伤均有一定的预防和治疗作用,常见的有黄酮类、酚类、生物碱类、萜类、皂苷类和蒽醌类等。中药干预对于ALD的治疗有广阔的应用前景。
Alcoholic liver disease (ALD) , a chronic liver disease caused by excessive alcohol consumption, seriously affects people's health, which has also been considered with the relevant to the elements including metabolites of alcoholic, oxidative stress, inflammation, cytokines, apoptosis, intestinal endotoxin and viral. Traditional Chinese medicines (TC- Ms) with the characteristics of multiple targets and treatment processes have good effects on reducing blood lipid, improving liver steatosis and preventing liver cirrhosis. Many kinds of active ingredients of TCMs including flavonoids, phenols, alkaloids, terpenoids, glycosides and anthraquinones have certain preventive and therapeutic effects on ALD. It has a broad application prospects on the intervention of ALD using TCMs.
出处
《大连医科大学学报》
CAS
2015年第4期313-319,共7页
Journal of Dalian Medical University
基金
高等学校博士学科点专项科研基金项目(20122105110004)
辽宁省高等学校创新团队项目(LT2013019)
关键词
酒精性肝病
中药
预防
干预
alcoholic liver disease
traditional Chinese medicine
prevention
intervention