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胰高血糖素样肽1对脂肪因子作用的研究进展

Research Progress in Glucagon-like Peptide-1 Effect on the Adipocytokines
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摘要 胰高血糖素样肽1(GLP-1)是目前用于治疗2型糖尿病的新型药物,因其以葡萄糖依赖方式刺激胰岛素释放而得到广泛应用。脂肪因子是由脂肪细胞分泌的活性因子,可以参与体内多种代谢功能的调节,并在许多疾病的发生、发展中发挥关键作用。因此,深入研究GLP-1对脂肪因子的调节作用,将为更好地应用GLP-1治疗代谢性疾病提供依据。 Glucagon-like peptide-1（ GLP-1） is widely used in the treatment of type 2 diabetes mellitus because of stimulating glucose-dependent insulin secretion in pancreatic β cells. Adipocytokines are secreted by adipocytes,involved in multiple metabolic functions in vivo and play a key role in the development of many diseases. The research on the regulation of GLP-1 to adipokines,will provide a new way to the treatment of metabolism diseases.
作者 肖元元 魏丽
机构地区 上海交通大学医学院附属第六人民医院内分泌代谢科上海市糖尿病研究所上海市糖尿病重点实验室
出处 《医学综述》 2015年第16期2884-2887,共4页 Medical Recapitulate
基金 国家自然科学基金(81370956) 上海交通大学无锡研究院交大专项资金(2011JDZX021)
关键词 胰高血糖素样肽1 脂肪因子 肥胖 Glucagon-like peptide-1 Adipocytokines Obesity
分类号 R589.2 [医药卫生—内分泌]
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参考文献40

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二级参考文献10

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医学综述
2015年 第16期

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