不同剂量阿托伐他汀治疗冠心病的临床效果比较

Clinical effect comparison of different dose atorvastatin treating coronary heart disease

目的 探讨不同剂量阿托伐他汀治疗冠心病的临床效果。方法 选取本院2012年6月~2014年6月收治的60例冠心病患者,采用随机数字表法将患者分为高剂量组与低剂量组,每组30例。高剂量组给予每日40 mg的阿托伐他汀治疗,低剂量组给予每日20 mg的阿托伐他汀组治疗,均以6个月为1个疗程,对比两组的临床疗效及不良反应发生情况。结果 两组治疗后的总胆固醇、三酰甘油、高密度脂蛋白及低密度脂蛋白较治疗前明显改善,高剂量组的各指标改善情况优于低剂量组（P〈0.05）;两组治疗后的心绞痛发作次数较治疗前明显减少,高剂量组的心绞痛发作次数明显少于低剂量组（P〈0.05）;高剂量组不良反应发生率为26.67%,低剂量组为33.33%,两组的不良反应发生率差异无统计学意义（P〉0.05）。结论 高剂量的阿托伐他汀治疗冠心病可显著降低血脂水平,减少心绞痛发作次数,同时具有较高的安全性,值得推广应用。

Objective To explore the clinical effect of different dose atorvastatin treating coronary heart disease（CHD）.Methods From June 2012 to June 2014,60 patients with CHD admitted into our hospital were selected and evenly divided into high-dose group and low-dose group using random number table method.In the high-dose group,40 mg atorvastatin daily was provided,while in low-dose group,only 20 mg atorvastatin each day was applied for therapy.Each course of treatment lasted 6 months in both groups.The clinical curative effect and occurrence of adverse reaction between two groups was compared respectively. Results The total cholesterol,triglyceride,high density lipoprotein and low density lipoprotein was significantly improved after treatment in two groups,and the improvement of high dose group was better than that of low dose group（P〈0.05）;the number of angina attacking in two groups was significantly decreased compared with that before treatment,and the number of angina attacking in high dose group was significantly fewer than that in low dose group（P〈0.05）;the incidence rate of adverse reaction in high-dose group was 26.67%,while in low-dose group,the incidence rate was 33.33%,and there was no statistical difference of incidence rate of adverse reaction between two groups（P〉0.05）. Conclusion High-dose atorvastatin treating CHD can greatly decrease blood lipid level and reduce the number of angina attacking,and has a higher safety.It is worthy of promotion and application.