HDL亚类和功能的研究进展

Research progresses of HDL subclasses and functions

高密度脂蛋白(HDL)是一种高度异质型脂蛋白,具有抗动脉粥样硬化(AS)作用。HDL因其密度、颗粒大小、电荷和组成成分不同,可分为不同的亚类,且功能各异。近年来研究发现,在糖尿病、冠心病等疾病情况下,HDL结构和功能发生改变,成为失功能性HDL,具有导致动脉粥样硬化的作用。本文就HDL的亚类、HDL的功能和失功能性HDL进行综述。

High density lipoprotein （HDL） is a highly heterogeneous lipoprotein, with effects on anti-athero- sclerosis. HDL has different kinds of subclasses and functions because of the differences in density, particle size, charge and composition. In recent years, the studies have found that in some diseases such as diabetes and coronary heart disease, HDL can turn into dysfunctional HDL which can cause atherosclerosis due to the change in structures and functions. This paper will summarize the hypotypes of HDL, function, and dysfunc- tional HDL.