阿司匹林对PICC置管后血浆中D-二聚体水平及静脉炎发生率的影响

The Effect of Aspirin on the D-dimer Level in Plasma and Incidence of Phlebitis After PICC

目的评估阿司匹林对中心静脉导管(PICC)置入后静脉炎的预防作用。方法将110例接受PICC置管的肿瘤患者,按有否使用阿司匹林分为两组。观察组:58例,PICC置管后,除给予常规PICC导管护理外,采用阿司匹林预防PICC置管后静脉炎形成;对照组:52例,PICC置管后,仅给予常规PICC导管护理。对比两组患者血浆中D-二聚体水平及静脉炎的发生情况。结果观察组和对照组血浆中D-二聚体水平,置管前后分别为:(0.86±0.09)mg/L、(0.89±0.10)mg/L(P>0.05)和(1.01±0.10)mg/L、(3.28±0.31)mg/L,(P<0.01);静脉炎的发生率分别为:5.2%和26.9%(P<0.01),对照组有2例(3.8%)发生血栓。结论阿司匹林能有效降低PICC置管后血浆中D-二聚体水平和静脉炎的发生率。

Objective To evaluate The effect of Aspirin t on the D- dimer level in plasma and the incidence of phlebitis after central venous catheter（ PICC）. Methods 110 cases of the tumors adopted the PICC were divided into two groups,according to with or not use of aspirin. Observation group（ n =58）,besides routine care for PICC,aspirin is used to prevent phlebitis after PICC; Control group（ n =52）,routine care only after PICC. And then compare the D- dimer level in plasma and the incidence rate of phlebitis in two groups. Results The level of D- dimer in plasma of observation group is（ 0. 86± 0. 09） mg / L、（ 0. 89 ± 0. 10） mg / L respectively,P 0. 05,and control group is（ 1. 01 ± 0. 10）mg / L、（ 3. 28 ± 0. 31） mg / L respectively,P 0. 01,before and after PICC. The incidence of phlebitis is respectively 5. 2% vs 26. 9%（P〈0. 01） of observation group and control group. 2 cases of blood clots in the control group. Conclusion Aspirin can effectively reduce the level of D- dimer in plasma and the incidence of phlebitis after PICC.