摘要
本实验旨在研究固体分散技术对吴茱萸碱(Evodiamine,EVO)的溶解度和溶出度的影响。以泊洛沙姆188(F68)为载体,熔融法制备吴茱萸碱固体分散体,通过X射线粉末衍射法、红外图谱分析药物在固体分散体中的存在状态和HLPC法测定EVO固体分散体的溶出度,采用相似因子f2分析不同处理方法对EVO固体分散体溶出度的影响。结果显示制备的分散体不影响EVO药物的含量和形态且大大提高EVO的溶出,该技术稳定可行且确定EVO与F68按1∶4为较优配比值。
The objective of this study was to investigate the effect of solid dispersion on dissolution and solubility of evo- diamine. The solid dispersion was prepared by melting method and poloxamer188 （F68） acted as the earrier. The distri- bution condition were analyzed using X-ray diffraction and infrared spectrum. The dissolution of the solid dispersions was detected by HLPC. Similarity faetorf2 was used to determine the effect of dissolution on different treatment methods. Ac- cording to the result of these tests, the dissolution of ultrafine EVO-F68 solid dispersion was evaluated. The results showed that evediamine solid dispersions technology can significantly increase the dissolution of EVO,which cannot af- fect the content and structure of EVO and even greatly improved the dissolution. The optimal ratio of EVO and F68 was 1： 4. Preferable solid dispersion was time-saving, highly efficient and reliable.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2015年第9期1626-1629,共4页
Natural Product Research and Development
基金
四川省中医药管理局科技项目(2012-G-032)
