Galetin-3与急性心梗后NYHA心功能分级的关系及阿托伐他汀对其干预作用

The Relationship between Galetin-3 and NYHA after Acute Myocardial Infarction and the Intervention Function of Atorvastatin on the NYHA Patients with after Acute Myocardial Infarction

目的:研究Galetin-3与急性心梗后NYHA心功能分级关系及阿托伐他汀对其干预作用。方法:选择2012年5月-2014年5月本院入院治疗的100例急性心梗患者作为试验研究对象,以随机数字法将所有患者分为观察组和对照组,每组各50例。再选取50例于本院进行体检结果显示健康人员作为健康组。观察组患者使用阿托伐他汀药物治疗,对照组患者使用临床普通的抗心衰药物治疗,观察两组急性心梗后心衰的干预情况,并对所有患者体内的Galetin-3水平进行检测,分析其对于急性心梗后心衰发生的预测价值。结果:两组治疗后Galetin-3含量均明显下降,但观察组患者下降更加明显,较对照组差异具有统计学意义(P<0.05)。治疗前,两组患者心功能指标水平比较差异无统计学意义(P>0.05);治疗后,两组的心功能水平较治疗前得到明显缓解,差异具有统计学意义(P<0.05)。治疗后,两组患者炎症因子TNF-α、IL-6以及Hs-CRP水平均明显下降,并且观察组的下降程度明显高于对照组,比较差异具有统计学意义(P<0.05)。不同NYHA分级患者NT-proBNP水平变化比较,等级为Ⅰ级时,治疗前后比较差异无统计学意义(P>0.05),其他级别治疗后NT-proBNP水平明显下降,比较差异有统计学意义(P<0.05)。结论:Galetin-3对急性心梗后心衰发生的预测具有十分重要的意义,并且使用阿托伐他汀对其干预作用效果较为显著,值得临床推广应用。

Objective： To study the relationship between Galetin-3 and NYHA after acute myocardial infarction and the intervention function of atorvastatin on the NYHA patients with after acute myocardial infarction. Method： 100 patients with acute myocardial infarction in our hospital from May 2012 to May 2014 were randomly divided into observation group and control group, 50 cases in each group, and 50 health cases as health group. The observation group was treated with atorvastatin, and the control group was treated with common anti heart failure drugs. The intervention of the two groups was observed after acute myocardial infarction, and the Galetin-3 levels of all patients were detected. Result： The Galetin-3 levels significantly decreased after treatment in the two groups, but the patients in the observation group were significantly lower than those in the control group （ P〈0.05 ） . There were no significant differences in cardiac function index between the two groups before treatment （ P〉0.05 ）, after treatment, the heart function level of the two groups was significantly relieved than before treatment, the difference was statistically significant （ P〈0.05 ） ） . After treatment, inflammatory factors TNF-et , IL-6 and Hs-CRP levels of the two groups patients significantly decreased, the difference was statistically significant （ P〈0.05 ）, and the observation group was significantly higher than that of the control group, the difference was statistically significant （ P〈0.05 ） . The different NYHA levels of NT-proBNP when was grade I, there was no difference before and after treatment （/~〉0.05 ）, but significantly decreased in the other grade after treatment （ P〈0.05 ） . Conclusion： Galetin-3 has a very important significance in predicting the occurrence of heart failure after acute myocardial infarction, and the effect of atorvastatin is more significant, which is worthy of clinical application.