期刊文献+

T淋巴细胞表达杀伤细胞抑制性受体的研究进展 被引量:1

Advances in the expression of killer cell inhibitory receptors by T cells
下载PDF
导出
摘要 Only in recent years, attentions have been drawn to the significance of expressing killer cell inhibitory receptors (KIR) in T cells KIRs specifically bind to the corresponding region of the MHC class I molecules and transmit negative signals to prevent cytotoxity of T cells. When the ligands of KIRs are missing, the lysis of the target cells can’t be avoided. Perhaps the existence of KIRs is the main mechanism for preventing T cells from attacking autologous tissues. The recognition mechanism of the interaction between the KIR + donor T cells and the recipient’s MHC class I molecule expressing tissue cells might shed light on the establishment of the immunotolerance for the prevention of allo-graft rejection and graft-versus-host disease. Only in recent years, attentions have been drawn to the significance of expressing killer cell inhibitory receptors (KIR) in T cells KIRs specifically bind to the corresponding region of the MHC class I molecules and transmit negative signals to prevent cytotoxity of T cells. When the ligands of KIRs are missing, the lysis of the target cells can't be avoided. Perhaps the existence of KIRs is the main mechanism for preventing T cells from attacking autologous tissues. The recognition mechanism of the interaction between the KIR + donor T cells and the recipient's MHC class I molecule expressing tissue cells might shed light on the establishment of the immunotolerance for the prevention of allo-graft rejection and graft-versus-host disease.
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2002年第8期999-1001,共3页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目 (No .30 1 70 395) 中国博士后科学基金资助项目 (No .2 0 0 1 - 2 9)
关键词 研究进展 杀伤细胞 T细胞 杀伤细胞抑制性受体 免疫耐受 免疫学 Killer cells T-lymphocytes Killer inhibitory receptors
  • 引文网络
  • 相关文献

参考文献2

二级参考文献4

共引文献9

同被引文献1

引证文献1

二级引证文献6

;
使用帮助 返回顶部