PO与TP方案治疗晚期宫颈癌的效果比较

Effect comparison of PO and TP regimens in the treatment of advanced cervical cancer

目的：比较紫杉醇联合奥沙利铂（PO方案）与紫杉醇联合顺铂（TP方案）治疗晚期宫颈癌的效果。方法选取2012年2月～2014年1月在本院就诊的60例晚期宫颈癌患者作为研究对象，按照随机数字表法分为观察组及对照组，各30例。观察组给予PO方案，对照组给予TP方案。比较两组的总有效率、疾病控制率（DCR），记录两组的无疾病进展期及不良反应发生率。结果两组的总有效率、DCR比较，差异无统计学意义（P〉0.05）。观察组的无疾病进展期显著长于对照组，差异有统计学意义（P〈0.05）。观察组的Ⅲ度＋Ⅳ度白细胞减少及恶心呕吐发生率显著低于对照组，差异有统计学意义（P〈0.05）。结论紫杉醇联合奥沙利铂治疗晚期宫颈癌的效果与紫杉醇联合顺铂相当，但无疾病进展期长，不良反应发生率低。

Objective To compare the therapeutic effect of paclitaxel with oxaliplatin （PO regimen） and paclitaxel with cisplatin （TP regimen） in the treatment of patients with advanced cervical cancer. Methods 60 patients with advanced cervical cancer from February 2012 to January 2014 in our hospital were selected and divided into the observation group and the control group according to random number table method,30 cases in each group.The observation group was given PO regimen,the control group was given TP regimen.The total effective rate,disease control rate （DCR） in two groups was compared,the progression-free survival and the incidence rate of adverse reaction in two groups was recorded. Results There was no significant difference in total effective rate or DCR rate between two groups （P〉0.05）. The progression-free survival in the observation group was longer than that in the control group,with significant differ-ence （P〈0.05）.The incidence rate of leucopenia,nausea and vomiting in degree Ⅲ andⅣ in the observation group was lower than that in the control group,with significant difference （P〈0.05）. Conclusion The effect of paclitaxel combined with oxaliplatin in the treatment of advanced cervical cancer is tantamount to the effect of paclitaxel combined with cisplatin,but the progression-free survival is long and adverse reaction is low.