胃铋镁四联疗法根除幽门螺杆菌的临床效果观察

Clinical observation of compound bismuth and magnesium combined with quadruple therapy in eradication of Helicobacter pylori

目的：观察胃铋镁四联疗法根除幽门螺杆菌（Hp）的临床效果。方法选取平顶山第二人民医院2013年1月～2014年12月的132例慢性胃炎或消化性溃疡合并Hp感染患者，将其随机分为治疗组和对照组，各66例。治疗组给予胃铋镁颗粒、兰索拉唑、阿莫西林、克拉霉素，对照组给予胶体果胶铋、兰索拉唑、阿莫西林、克拉霉素，两组均口服14 d。治疗后，两组复查14C-尿素呼气试验，比较Hp根除率；治疗过程中观察两组患者的不良反应发生情况。结果治疗组的Hp根除率为93.9%（62/66），对照组为90.9%（60/66），两组差异无统计学意义（P〉0.05）。治疗组的不良反应发生率为3.0%，显著低于对照组的13.6%，差异有统计学意义（P〈0.05）。两组均未见严重不良反应。结论胃铋镁四联疗法根除Hp的疗效确切，且不良反应发生率低于胶体果胶铋四联疗法，具有更高的安全性，值得临床推广。

Objective To observe the clinical effect of compound bismuth and magnesium combined with quadruple therapy in eradication of Helicobacter pylori（Hp）. Methods 132 patients with chronic gastritis or peptic ulcer combined with Hp infection in Pingdingshan second people’s hospital from January 2013 to December 2014 were selected.They were randomly divided into treatment group and control group,each group was 66 cases.The treatment group was given stomach bismuth magnesian particle,lansoprazole,amoxicillin and clarithromycin. Control group was given colloidal bis-muth pectin,lansoprazole,amoxicillin and clarithromycin.Two groups were oral treated for 14 days.After treatment,the eradication rate of Hp was compared by reviewing 14C- urea breath test.The adverse effect in two groups was observed during treatment. Results The eradication rate of Hp in treatment group was 93.9%（62/66）,in control group was 90.9%（60/66）,the difference was significant between two groups （P〉0.05）.The digestive tract adverse effect rate in treatment group was 3.0%,which was significantly lower than 13.6%of control group,and the difference was statistical significance （P〈0.05）.There was no serious adverse effect occurred between two groups. Conclusion Compound bismuth and magne-sium combined with quadruple therapy has exact effect in eradication of Hp,and the occurrence of adverse effect rate lower than compound colloidal bismuth pectin combined with quadruple therapy.It has a higher safety and worth popu-larizing in clinical.