抗精神病药物联合MECT治疗对精神分裂症患者性激素水平的影响

Effects of antipsychotic combined with MECT on sexual hor- mone levels of patients with schizophrenia

目的探讨抗精神病药物联合无抽搐电休克治疗对精神分裂症患者性激素水平的影响。方法将78例精神分裂症患者随机分成研究组和对照组各39例，两组均口服新型非典型抗精神病药物治疗，研究组联合无抽搐电休克治疗，观察4周。治疗前后检测两组血清睾酮、催乳素、雌二醇的变化。结果治疗后两组男性患者催乳素水平均较治疗前显著升高（P〈0．05或0．01），治疗4周末研究组男性患者催乳素水平显著低于对照组（P〈0．05）；研究组女性患者催乳素水平较治疗前有所下降，对照组有所升高，但与治疗前比较差异无显著性（P〉0．05）。治疗前后研究组男、女患者血清睾酮水平均无显著变化（P〉0．05），对照组男、女患者则均较治疗前显著升高（P〈0．05或0．01），治疗4周末对照组男、女患者血清睾酮水平均显著高于研究组（P〈0．05）；两组男、女患者治疗前后雌二醇水平检测结果均无显著变化（P〉0．05）。结论抗精神病药物联合无抽搐电休克治疗对抗精神病药物导致精神分裂症患者催乳素、血清睾酮水平的升高有不同程度抑制作用。

Objective To explore the effects of antipsychotic combined with modified electroconvulsive therapy （MECT） on sexual hormone levels of patients with schizophrenia. Methods Seventy-eight schiz- ophrenics were randomly divided into 2 groups of 39 ones each, both groups treated with oral novel atypi- cal antipsychotic, research group was plus MECT for 4 weeks. Serum testosterone （T）, prolactin （PRL） and estradiol （E2） changes were detected before and after treatment. Results After treatment PRL levels of male patients of both groups heightened more significantly compared with pretreatment （P〈0.05 or 0.01）, that was significantly lower in research than in control group at the end of the 4th week （P〈0.05） PRL levels of female patients lowered somewhat in research and heightened in control group, but had no significant differences compared with pretreatment （P〉0.05）. Post-treatment serum T had no significant difference from pretreatment in research （P〉0. 05） and heightened more significantly in control group （P〈0.05 or 0.01）, at the end of the 4th week serum T level was significantly higher in control than in re- search group （P〈0.05） ; there were no significant changes in E2 （P〈0.05）. Conclusion Antipsychotic combined with MECT has an inhibitory action in different degrees on the elevation of serum PRL and T in- duce by antipsychotic.