摘要
以银杏内酯A,B,K转移率为综合评价指标,选取活性炭加入量、吸附时间、搅拌速度和吸附温度为影响因素,采用正交试验设计方法,同时采用基于信息熵的综合评价方法,筛选银杏二萜内酯葡胺注射液活性炭吸附工艺,确定最佳活性炭吸附工艺为活性炭加入量为0.2%,吸附温度为25℃,搅拌速度为40 r·min-1,吸附时间为30 min,验证试验结果显示,优选得到的工艺稳定、可行,为银杏二萜内酯葡胺注射液的活性炭吸附工艺提供了依据。
With the diversion rate of ginkgolide A,B,K as comprehensive evaluation indexes,the amount of activated carbon,adsorption time,mix rate,and adsorption temperature were selected as factors,orthogonal design which based on the evaluation method of information entropy was used to optimize activated carbon adsorption technology of ginkgo diterpene lactones meglumine injection. Optimized adsorption conditions were as follows： adsorbed 30 min with 0. 2% activated carbon in 25 ℃,40 r·min^-1,validation test result display. The optimum extraction condition was stable and feasible,it will provide a basis for ginkgo diterpene lactone meglumine injection＇ activated carbon adsorption process.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第20期3993-3997,共5页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2013ZX09402203)
江苏省科技成果转化项目(BA2010109)
关键词
银杏二萜内酯葡胺注射液
银杏内酯
活性炭
正交试验
信息熵
ginkgo diterpene lactones meglumine injection
ginkgo lactone
activated carbon
orthogonal test
information entropy
