补肾健骨方治疗慢性肾脏病-矿物质和骨异常35例临床观察

Bushen Jiangu Decoction in the Treatment of Mineral and Bone Disorder of Chronic Kidney disease: Clinical Observation of 35 Cases

目的:观察补肾健骨方治疗慢性肾脏病-矿物质和骨异常(CKD-MBD)的临床疗效。方法:将符合纳入标准的70例患者按随机数字表法分为治疗组、对照组,35例。对照组给予常规治疗,治疗组于常规治疗基础上加服补肾健骨方,疗程4周。观察两组患者的总疗效及治疗前后血清肌酐(Scr)、尿素氮(BUN)、尿酸(UA)、内生肌酐清除率(CCr)、Ca、P、全段甲状旁腺激素(i PTH)的变化;结果:治疗组有效率为82.9%,优于对照组的65.7%(P<0.05);治疗后治疗组BUN水平低于对照组(P<0.05),两组患者Scr、UA、Ca水平比较差异无统计学意义(P>0.05);两组患者血清P、i PTH水平低于治疗前(P<0.05,P<0.01),治疗组优于对照组(P<0.05)。结论:补肾健骨方有助于缓解CKD-MBD患者的临床症状,并在降低尿素氮、血磷及甲状旁腺激素水平、调节钙磷代谢方面具有一定的作用。

Objective： To observe the effect of Bushen Jiangu decoction in the treatment of mineral and bone disorder chronic kidney disease of（ CKD- MBD）. Methods： A total of 70 patients who met the inclusion criteria were randomly divided into a treatment group and a control group,with 35 cases in each group. The control group was given conventional treatment,and the treatment group was based on the routine treatment plus orally taking Bushen Jiangu decoction,with 4 weeks as a course of treatment. Observe the total effect in two groups according to seram creatinine（ Scr）,blood urea nitrogen（ BUN）,uric acid（ UA）,creatinine clearance rate（ CCr）,Ca,P,intact parathyroid hormone（ i PTH） changes before and after treatment. Results： The effective rate in the treatment group was 82. 9%,which was better than 65. 7% in the control group（ P〈0. 05）; after treatment,BUN in the treatment group was lower than that in the control group（ P〈0. 05）,and the two groups had no statistical significance according to Scr,UA,Ca（ P〈0. 05）; the serum P,i PTH levels in two groups were lower than those before treatment（ P〈0. 05,P〈0. 01）,and the treatment group was superior to the control group（ P〈0. 05）. Conclusion： Bushen Jiangu decoction can relieve the clinical symptoms of patients with CKD- MBD,and it plays a role in reducing blood urea nitrogen,serum phosphorus and parathyroid hormone levels,regulating calcium and phosphorus metabolism.