抗生素降阶梯治疗重症监护病房呼吸机相关性肺炎的临床探讨

Clinical Observation of Antibiotic De-escalation Therapy for Ventilator-associated Pneumonia in ICU

目的研究和探讨对重症监护病房呼吸机相关性肺炎患者采用抗生素降阶梯治疗的临床情况及效果。方法随机选择2012年6月—2014年6月以来,在该院重症监护病房进行治疗的呼吸机相关性肺炎患者88例。将他们根据抽签法划分成对照组和观察组(各有44例),对照组实施常规治疗方法进行临床治疗,观察组使用抗生素降阶梯方法进行临床治疗,对两组患者的治疗效果进行分析、比较和统计。结果经过统计学分析显示,观察组患者在抗生素使用时间、机械通气时间、感染控制时间、住院时间以及临床总有效率(93.18%)方面均显著高于对照组的61.36%,组间对比的差异具有统计学意义(P<0.05)。结论使用抗生素降阶梯疗法对重症监护病房呼吸机相关性肺炎患者进行临床治疗的效果明显,治疗时间短。因此,它是一种科学、理想、有效的临床治疗方法。

Objective To study and discuss the clinical situation and effect of de-escalation therapy for ventilator-associated pneumonia in patients using antibiotics. Methods 88 cases treated with ventilator associated pneumonia patients in ICU were random selected in June 2012 to June 2014, They will be divided into two groups according to the draw method average（each group has44 cases）, the patients in the control group using conventional methods of clinical treatment, the observation group were treated with antibiotic escalation method in clinical treatment, and comparison, statistics and analysis of two groups of patients with clinical diagnosis and effect. Results The statistical comparison shows, patients in the observation group use time, mechanical ventilation time, infection control time, hospitalization time and the total clinical effective rate in antibiotics（93.18%） were significantly better than the control group（61.36%）, differences between the groups were significant, with statistical significance（P〈0.05）.Conclusion The use of antibiotic de-escalation therapy for clinical treatment of ventilator-associated pneumonia in patients with obvious effect, short treatment time. Therefore, it is a kind of ideal, scientific, effective clinical treatment method.