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间充质干细胞的免疫调节作用及其与白血病相关性的研究

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摘要 间充质干细胞（mesenchymal stem cell,MSC）能够从多种组织的基质细胞分离,具有多向分化潜能、低免疫原性、免疫调节作用并可迁移到受损伤组织促进组织修复等特征,在移植物抗宿主病（GVHD）和肿瘤的治疗中有着广泛的应用前景。而近来有报道显示MSC有促进和抑制免疫的双重作用,对肿瘤的作用存在争议且许多造血系统疾病与骨髓间充质干细胞（BMSC）有关,本文就MSC的免疫学特性和MSC与白血病（血液系统肿瘤）的关系的最新进展予以综述。
作者 王亚萍 司英健
机构地区 北京军区总医院附属八一儿童医院血液肿瘤科 山西医科大学
出处 《中国小儿血液与肿瘤杂志》 CAS 2015年第6期319-323,共5页 Journal of China Pediatric Blood and Cancer
基金 国家自然科学基金项目资助(编号:31300474)
关键词 间充质干细胞 免疫调节作用 白血病细胞 血液系统肿瘤 移植物抗宿主病 造血系统疾病 损伤组织 免疫学特性 基质细胞 免疫原性
分类号 R733.7 [医药卫生—肿瘤]
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参考文献47

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二级参考文献71

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中国小儿血液与肿瘤杂志
2015年 第6期

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