临床麻醉及疼痛治疗中应用不同浓度罗哌卡因的效果观察

The effect observation on applying ropivacaine in clinical anesthesia and pain treatment

目的观察临床麻醉及疼痛治疗中应用罗哌卡因的效果。方法将我院120例拟行胸部手术治疗且采用硬膜外麻醉者作为研究对象,按照随机数字表法分组为对照组(0.25%罗哌卡因)与观察组(0.2%罗哌卡因),各60例。统计2组患者术后自主呼吸恢复时间、意识恢复时间、术后心率、拔管时间、平均动脉压及脉搏氧饱和度,统计2组患者术后1、2、4、6h疼痛情况,观察2组药物不良反应等。结果 2组患者术后自主呼吸恢复时间、意识恢复时间、术后心率、拔管时间、平均动脉压及脉搏氧饱和度比较差异无统计学意义(P>0.05);观察组患者于术后1、2、4、6h视觉模拟评分(VAS)明显低于对照组(P<0.05)。2组不良反应率比较差异无统计学意义(P>0.05)。结论应用0.2%罗哌卡因具有较好麻醉及镇痛效果。

Objective To observe the effect of ropivacaine on clinical anesthesia and pain treatment. Methods We take 120 patients who will have chest surgery and epidural anesthesia in our hospital as the objects of this research. They are equally divided into control group （0.25 % ropivacaine） and observation group （0.20% ropivacaine） according to random number table. Each group has 60 patients. Autonomous respiration recovery time, consciousness recovery time, post-operation heart rate, tube drawing time, mean arterial pressure and pulse oxygen saturation of two groups＂ patents after operation are recorded. The pain condition of two groups＂ patients after 1, 2, 4 and 6 h is observed. The adverse drug reaction of two groups is observed. Results Autonomous respiration recovery time, consciousness recovery time, post-operation heart rate, tube drawing time, mean arterial pressure and pulse oxygen saturation of two groupsr patents after operation are compared, and the difference isn＇t significant （P〉0.05）; the VAS scores of observation group 1, 2, 4 and 6 h after operation are significantly lower than those of control group （P〈0.05）. Untoward effect rates of two groups are compared, the difference isnrt significant （P〉0.05）. Conclusion The 0.2% ropivacaine has a better anesthetic and analgesic effect.