奥硝唑治疗妇科肿瘤患者术后厌氧菌盆腔感染的临床研究

Clinical efficacy and safety of ornidazole in treatment of postoperative pelvic infections caused by anaerobic bacteria in tumor patients of gynecology department

目的探讨奥硝唑对妇科肿瘤患者术后厌氧菌盆腔感染的临床疗效及安全性,为临床合理用药提供参考依据。方法选取医院2011年4月-2015年1月收治的妇科肿瘤术后厌氧菌盆腔感染患者80例,将其随机分为对照组和观察组,每组各40例,对照组患者给予替硝唑治疗,观察组给予奥硝唑治疗,比较两组患者整体治疗效果、细菌学疗效与药物不良反应发生率;采用SPSS19.0软件对数据进行统计分析。结果患者治疗总有效率观察组为97.5%,明显高于对照组的77.5%,差异有统计学意义(P<0.05);观察组患者金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌与粪肠球菌单独清除率与对照组差异无统计学意义,但病原菌总清除率明显高于对照组,差异有统计学意义(P<0.05);观察组患者大肠埃希菌、肺炎克雷伯菌、鲍氏不动杆菌、奇异变形菌单独清除率与对照组差异无统计学意义;观察组患者药物不良反应发生率为25.0%,明显低于对照组的47.5%,差异有统计学意义(P<0.05)。结论奥硝唑对妇科肿瘤术后厌氧菌盆腔感染患者的临床疗效显著,且安全性较好,具有借鉴性。

OBJECTIVE To explore the clinical efficacy and safety of ornidazole in treatment of postoperative pelvic infections caused by anaerobic bacteria in tumor patients of gynecology department so as to provide guidance for reasonable clinical use of antibiotics.METHODS A total of 80 patients with postoperative pelvic infections caused by anaerobic bacteria who were treated in the hospital from Apr 2011 to Jan 2015 were enrolled in the study and randomly divided into the control group and the observation group,with 40 cases in each.The control group was treated was tinidazole,while the observation group was treated with ornidazole.The overall curative effect,bacteriological efficacy,and incidence of drug-induced adverse reactions were observed and compared between the two groups of patients;the statistical analysis of data was performed with the use of SPSS19.0software.RESULTS The total effective rate of treatment of the observation group was 97.5%,significantly higher than 77.5% of the control group,and there was significant difference（P〈0.05）.As compared with the clearance rate of Staphylococcus aureus,Staphylococcus epidermidis,Staphylococcus haemolyticus,or Enterococcus faecalis,separately,there was no significant difference between the observation group and the control group,however,the total clearance rate of the pathogens of the observation group was significantly higher than that of the control group,and there was significant difference（P〈0.05）.There were no significant differences in the single clearance rate of Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,or Proteus mirabilis and the total clearance rate of the pathogens between the observation group and the control group.The incidence of the drug-induced adverse reactions was 25.0% in the observation group,significantly lower than 47.5% in the control group,and there was significant difference（P〈0.05）.CONCLUSION Ornidazole can achieve significant clinical effect on treatment of the postoperative pelvic infections caused by anaerobic bacteria in the tumor patients of gynecology department,and it is safe and reliable.