nm23重组质粒与肿瘤关系研究进展

Research progress of the relationship between nm23 recombinant plasmid and tumor

转移抑制基因nm23在肿瘤细胞增殖、分化和侵袭转移中发挥重要作用,其超表达与肿瘤的分化程度、临床分期、组织学分级及淋巴结转移等密切相关。近年来携带抑癌基因nm23的重组质粒转染肿瘤细胞成为临床研究的热点。本文就nm23重组质粒与肿瘤关系的研究进展作一综述。

Being a metastasis suppressor gene, rim23 plays an important role in the proliferation, differentiation, invasion and metastasis of tumor cell. The overexpression of nm23 gene is closely correlated with tumor differentiation degree, clinical stage, histological grade and lymph node metastasis. In recent years, transfecting the tumor ceils with the recombinant plasmid carrying tumor-suppressor gene nm23 has become the hot topic. This paper reviews the research progress of the relationship between nm23 recombinant plasmid and tumor.