羟苯磺酸钙联合血栓通对糖尿病视网膜病变致患者视野缺损的临床疗效

Efficacy of calcium dobesilate combined with Xueshuantong on patients with visual field defect induced by diabetic retinopathy

目的观察羟苯磺酸钙联合复方血栓通对糖尿病视网膜病变致患者视野缺损的临床疗效。方法 346例糖尿病视网膜病变患者随机分为试验组173例和对照组173例。对照组口服血栓通每次1.5 g,每天3次;试验组在对照组的基础上联合羟苯磺酸钙,每次0.5 g,每天3次,2组疗程均为6个月。评价患者治疗后的临床疗效,比较2组患者治疗前后血管瘤、黄斑厚度、出血斑、视力情况、视野灰度、30°内阈值敏感程度及血常规、肝肾功能变化。结果治疗后,试验组患者总有效率(95.95%)显著高于对照组(78.03%,P<0.05)。2组治疗后临床症状均较治疗前显著改善,试验组血管瘤、黄斑厚度、出血斑指标改善效果优于对照组(P<0.05)。试验组视力情况、视野灰度值及30°内阈值敏感程度的改善效果优于对照组(P<0.05)。治疗前后,2组血常规和肝肾功能均无明显变化(P>0.05)。结论羟苯磺酸钙联合复方血栓通治疗糖尿病视网膜病变,临床症状得到明显改善,临床疗效良好,安全性高。

Objective To evaluate the clinical efficacy of calcium dobesilate combined with Xueshuantong on visual field defects caused by diabetic retinopathy（ DR） in patients. Methods A total of 346 patients with DR were divided into treatment group（ 173 cases） and control group（ 173 cases）. Control group was given Xueshuantong 1. 5 g,tid,treatment group was treated with dobesilate calcium 0. 5 g,tid,on the basis of control group. The total course of the two groups was six months. The clinical efficacy,hemangioma,macular thickness and bleeding spots,vision acuity,vision gray value,within 30° threshold sensitivity improvement,blood,liver and kidney function of the two groups were observed.Results After treatment,the total effective rate of treatment group（ 95. 95%） was significantly higher than that in control group（ 78. 03%,P〈0. 05）. The hemangioma,macular thickness and bleeding spots improvement in treatment group were better than those in control group（ P〈0. 05）. Visual acuity,vision gray value and within 30° threshold sensitivity improvement in treatment group were better than those in control group（ P〈0. 05）. The blood,liver and kidney function of the two groups had no significant difference（ P〉0. 05）. Conclusion For the treatment of diabetic retinopathy, calcium dobesilate combined withXushuangtong can significantly improve the clinical symptoms,and had good clinical effect with high safety.