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精子DNA碎片指数与IVF/ICSI成功率的关系 被引量:17

Sperm DNA fragmentation index and the success rate of IVF/ICSI
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摘要 精子DNA碎片指数(DFI)是指发生DNA链断裂的精子占全部精子的百分比。已有的一些研究显示,高DFI可能会导致男性不育或者女性早期流产。目前已有一些研究显示,DFI升高可导致自然妊娠率降低及早期自然流产率升高,并且在辅助生殖过程中,高DFI的患者更容易失败。此外,对高DFI患者已有初步的治疗方案或预防方法。本文综述了DFI对自然妊娠以及IVF/ICSI妊娠结局的影响以及对DFI增高的治疗方法的研究现状与进展。 Sperm DNA fragmentation index( DFI) refers to the percentage of DNA strand breaks in the total sperm. Many studies suggest that elevated DFI can lead to male infertility and early spontaneous abortion. High-DFI patients are more likely to fail in assisted reproduction and preliminary treatment or prevention methods have been developed for this population. This review focuses on the impact of DFI on clinical pregnancy outcomes and progress in the studies of its treatment.
出处 《中华男科学杂志》 CAS CSCD 北大核心 2016年第1期77-81,共5页 National Journal of Andrology
基金 国家自然科学基金(81270694) 南京市医学重点项目(ZKX13032)~~
关键词 精子DNA碎片指数 IVF/ICSI 着床率 sperm DNA fragmentation index IVF/ICSI implantation rate
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