胃癌组织中VEGF-D及MLVD表达及其与预后的关系

Relationship between Expression of VEGF-D and MLVD in Gastric Cancer Tissues and Prognosis

目的探讨胃癌患者肿瘤组织中血管内皮生长因子-D(vascular endothelial growth factor-D,VEGF-D)及微淋巴管密度(micro-lymphatic vessel density,MLVD)与其生存期的关系。方法收集52例胃癌术后患者标本,采用免疫组化方法检测胃癌组织中VEGF-D、MLVD及胃癌癌旁MLVD。结合临床病理资料,分析VEGF-D、MLVD与其生存期的关系。结果胃癌组织VEGF-D阳性组生存期较阴性组短(P=0.048),两者间差异有统计学意义;癌旁组织MLVD高组(≥10)较低组(<10)生存期短(P=0.001),两者间差异有统计学意义;胃癌组织MLVD高组(≥10)较低组(<10)生存期短(P=0.067),但差异无明显统计学意义。结论胃癌组织中VEGF-D及胃癌癌旁MLVD可作为判断胃癌预后的指标。

Objective To study the relationships between expression of vascular endothelial growth factor-D（ VEGF-D）and micro-lymphatic vessel density（ MLVD） of gastric cancer tissues and overall survival. Methods 52 samples of resected gastric cancer were gathered. The expression of VEGF-D in gastric cancer,intratumoral MLVD and peritumoral MLVD were stained immunohistochemically. Clinical data and stastistical analysis were combined to find the relationship in VEGF-D,MLVD and overall survival. Results The overall survival of VEGF-D positive group was significantly shorter than that of negative group（ P =0. 048）. There was statistical difference between the 2 groups. The overall survival of peritumoral high MLVD group（ ≥10） was significantly shorter than that of low MLVD group（ 〈10）（ P = 0. 001）. There was statistically difference between the 2 groups.But the overall survival of intratumoral high MLVD group（ ≥10） was not statistically shorter than low MLVD group（ 〈10）（ P =0. 067）. Conclusion The detection of VEGF-D and peritumoral MLVD in the tissue of gastric cancer can be regarded as unfavorable prognostic indicator for patients with gastric cancer.