植物SUMO化修饰研究进展

Advances of sumoylation in plants

SUMO(Small ubiquitin-related modifier)化作为一种重要的真核生物翻译后修饰方式,广泛参与真核细胞的各种代谢调控过程。SUMO化修饰过程是一个动态、可逆的循环,需要经过一系列步骤,如SUMO分子的活化、E1激活酶、E2缀合酶、E3连接酶和特异性蛋白酶的去SUMO化。植物的SUMO化修饰参与了植物对激素的响应、花的发育、开花控制、营养元素的吸收和逆境响应等重要生物学过程。近年来,SUMO 化已成为植物功能基因研究中的新生长点。以拟南芥和水稻为主,综述了SUMO化修饰过程的组成成分、SUMO化与植物对激素响应的关系、SUMO化参与的植物开花控制、SUMO化与植物对非生物胁迫的响应等方面的研究现状,并对植物SUMO化研究中存在的问题提出建议,以期更好地理解SUMO化修饰在植物生长发育中的作用。

Sumoylation is one of the essential post-translational modifications in eukaryotes, and it plays an important role in various cellular regulatory processes. Sumoylation is a dynamic, reversible cycle, consisted of a series of biochemical reactions, including SUMO E1 activation, E2 conjugation, E3 ligation and deconjugation of SUMO substrates catalyzed by ubiquitin-like SUMO-specific proteases. Sumoylation plays key roles in hormone response, flower development, flowering time regulation, nutrient absorption and environmental adversities. In recent years, sumoylation has become the new growth point of functional gene research in plants. Following is a brief overview of the current understanding of sumoylation in Arabidopsis and rice, we first introduce the important components in the sumoylation pathway, and then review the current progress that SUMO modification regulates plant growth and development, including the response to signal of hormone and abiotic stress, flower development and flowering time regulation. Finally, suggestions are presented for future research of sumoylation according to previous studies. It is expected to provide a basis for better understanding the roles of sumoylation of proteins in plants.