D-半乳糖AD模型与中医脑衰老证候病机关系的探讨及在针灸防治脑衰老中的应用

Discussion on Correlation Between D-galactose Induced Alzheimer's Disease Model and the Traditional Chinese Medicine(TCM) Syndrome Pathogenesis of Brain Aging and the Application of Acupuncture Prevention in Brain Aging

D-半乳糖衰老动物模型已成为国内外较公认的衰老动物模型,历代医家已经认识到了肾虚脑髓失养,痰浊瘀血是痴呆的主要病机。基于对老年痴呆主要包括阿尔茨海默病(Alzheimer's Disease,AD)的认识,认为D-半乳糖所诱导的AD模型与中医脑衰老中的肾虚脑髓失养,痰瘀内阻证型在一定程度上相符合。本文拟从行为学、形态学及病理结构等方面进行阐述。

D-galactose induced Alzheimer＇s disease（ AD） model has been widely acknowledged as the aging model both at home and abroad. Previous doctors have recognized that the deficiency of brain marrow caused by kidney deficiency as well as phlegm turbidity and blood stasis are the main pathogenesis of dementia. Based on the study of dementia in old age including AD,it is recognized that D-galactose induced Alzheimer＇s disease model is somewhat coincided with the type of deficiency of brain marrow due to kidney deficiency,which was further discussed in this paper under the perspective of behavior,morphology and histopathology etc.