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Emerging roles of non-coding RNAs in gastric cancer:Pathogenesis and clinical implications 被引量:7

Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications
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摘要 Gastric cancer is a leading cause of cancer-related deaths. However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The association of non-coding RNAs(nc RNAs) with cancer has been widely studied during the past decade. In general, nc RNAs have been classified as small nc RNAs, including micro RNAs(mi RNAs), and long non-coding RNAs(lnc RNAs). Emerging evidence shows that mi RNAs and lnc RNAs play key roles in the formation and progression of many cancers. In this review, we focus on the regulation of mi RNAs and lnc RNAs in gastric cancer. mi RNAs and lnc RNAs appear to be involved in gastric tumor growth, invasion, and metastasis and in establishment of the gastric tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing mi RNAs and lnc RNAs as potential biomarkers and therapeutic targets for gastric cancer. Taken together, we summarize the emerging roles of nc RNAs in gastric cancer development and their possible clinical significance. Gastric cancer is a leading cause of cancer-related deaths. However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The association of non-coding RNAs(nc RNAs) with cancer has been widely studied during the past decade. In general, nc RNAs have been classified as small nc RNAs, including micro RNAs(mi RNAs), and long non-coding RNAs(lnc RNAs). Emerging evidence shows that mi RNAs and lnc RNAs play key roles in the formation and progression of many cancers. In this review, we focus on the regulation of mi RNAs and lnc RNAs in gastric cancer. mi RNAs and lnc RNAs appear to be involved in gastric tumor growth, invasion, and metastasis and in establishment of the gastric tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing mi RNAs and lnc RNAs as potential biomarkers and therapeutic targets for gastric cancer. Taken together, we summarize the emerging roles of nc RNAs in gastric cancer development and their possible clinical significance.
出处 《World Journal of Gastroenterology》 SCIE CAS 2016年第3期1213-1223,共11页 世界胃肠病学杂志(英文版)
基金 Ministry of Science and Technology of China No.2012CB945004,No.2013CB945603 Natural Scientific Foundation of China No.31125017 No.31190063 No.31100975 No.31301149 and No.31471259 Ministry of Education of China No.20110101110103,No.20130101120001 Natural Scientific Foundation of Zhejiang Province China No.LQ13H160013 No.LY14C070001 and No.LY14C070002 Zhejiang Province Key Science and Technology Innovation Team No.2013TD13 Fundamental Research Funds for the Central Universities No.2014QNA7015 the 111 Project No.B13026
关键词 microRNAs Long NON-CODING RNAS Gastriccancer Cancer INVASION METASTASIS micro RNAs Long non-coding RNAs Gastric cancer Cancer invasion Metastasis
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