乙型肝炎病毒感染患者肝癌发病的影响因素研究

Risk factors of liver cancer in patients with hepatitis B virus infection

目的 探究乙型肝炎病毒感染患者肝癌发病的影响因素,为制定有效的预防措施提供参考依据.方法 选择2013年1月至2015年6月在我市一级以上医院接受治疗的乙型肝炎病毒感染并发肝癌患者90例为研究组.选择同期接受治疗的乙型肝炎病毒感染患者90例为对照组.比较两组患者的临床资料,用单因素分析和Logistic回归分析其影响因素.结果 乙型肝炎病毒感染患者并发肝癌与糖尿病、长期饮酒史、不良饮食、HBV DNA（＋）、HBSAg（＋）、HBeAg（＋）、抗-HBS（＋）、抗-HBe（＋）、抗-HBc（＋）、谷草转氨酶（AST）、肝癌家族史、其他肿瘤家族史和未抗病毒有关,差异具有统计学意义（P＜0.05）.将上述因素纳入Logistic多元回归分析,结果显示糖尿病、长期饮酒史、不良饮食、HBV DNA（＋）、HBSAg（＋）、抗-HBe（＋）、肝癌家族史、未抗病毒是引起乙型肝炎病毒感染患者发生肝癌的独立危险因素（P＜0.05）.结论 对肝癌发病的危险因素存在较多的乙型肝炎病毒感染患者给予密切关注,早期行抗病毒治疗.

Objective To explore the risk factors of liver cancer in patients with hepatitis B virus infection,and to explore effective preventive measures.Methods 90 patients with hepatitis B virus infection complicated with liver cancer who treated in sentinel hospital were selected as research group from January 2013 to June 2015.90 patients with hepatitis b virus infection without liver cancer were selected in the same period as the control group.The clinical data of two groups of patients were compared with single factor analysis and Logistic regression to analyze its influencing factors.Results Patients with hepatitis B virus infection complicated with liver cancer had correlation with diabetes,long history of drinking,poor diet,HBV DNA （＋）,HBSAg （＋）,HBeAg （＋）,anti-HBS （＋）,anti-HBe （＋）,anti-HBc （＋）,AST,family history of liver cancer and other tumors without antiviral treatment and there was significantly differences （P 〈 0.05）.The above factors were also analyzed by the Logistic multivariate regression analysis and the results showed that history of diabetes,long-term drinking,poor diet,HBV DNA （＋）,HBSAg （＋）,anti-HBe （＋）,family history of cancer of the liver and no antiviral treatment were independent risk factors for liver cancer （P 〈 0.05）.Conclusions Hepatitis B patients with the risk factors of liver cancer should be paid close attention and early treatment of antiviral therapy.