RB1在恶性肿瘤中的研究进展

The research progresses on RB1 in malignant tumors

视网膜母细胞瘤基因1（Retino blastomal，RB1）是人类发现的第一个抑癌基因，因为最初在视网膜母细胞瘤中发现该基因所以命名为视网膜母细胞瘤基因1。RB1作为一种负性调控因子在细胞周期中有重要作用，通过与转录因子E2F结合来调控细胞的增殖。研究还发现RB1在抗细胞凋亡中也扮演着重要的角色，RB1的敲除可以增强抗肿瘤药物导致细胞死亡的敏感性。RB1的这种双重作用提示其可能是恶性肿瘤的发病原因，并且可能成为肿瘤进展及临床治疗效果的预测指标。

The RBI gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer, the pediatric cancer retinoblastorna. As a negative regulator of the cell cycle, RB1 gene could regulate the expression of genes involved in cell proliferation through binding to transcription factor E2F. Among these, RB1 has been implicated in the regulation of apoptosis. RB1 knockdown has been shown to enhance the sensitivity to cell death induced by different anticaneer agents. RB1 dual role in proliferation and apoptosis underlies malignant tumor occurrence, development and resistance totherapy.