长春西汀联合丹红注射液治疗急性脑梗死的临床疗效及其对血液流变学的影响

Clinical effects of vinpocetine combined with Danhong injection for patients with acute cerebral infarction and its impact on hemorheology

目的探讨长春西汀联合丹红注射液治疗急性脑梗死的临床疗效及其对血液流变学的影响。方法选取2013年1月-2015年1月收治的108例急性脑梗死患者为研究对象,按治疗方法的不同分为观察组和对照组,每组54例,比较两组患者临床疗效、血液流变学指标、药物不良反应发生情况。结果治疗后两组美国国立卫生研究院卒中量表（NIHSS）评分均较治疗前有所下降（P〈0.01）,但观察组明显低于对照组（P〈0.01）。治疗后两组血液流变学指标较治疗前有所下降,观察组患者下降较对照组明显,两组差异有统计学意义（P〈0.01）。治疗后两组药物不良反应发生率相比无统计学意义（P〉0.05）。结论长春西汀联合丹红注射液治疗急性脑梗死的临床疗效明显优于单用长春西汀的疗效,值得在临床上推广使用。

Objective To investigate the clinical effects of vinpocetine combined with Danhong injection for patients with acute cerebral infarction and its impact on hemorheology. Methods From January 2013 to January 2015,108 cases of acute cerebral infarction were selected as study objects and randomly divided into observation group and control group,with 54 cases in each. Then,clinical effects,hemorheology indexes and drug adverse reactions were compared between the two groups.Results After treatment,U. S. National Institutes of Health Stroke Scale（ NIHSS） scores of both groups were lower than those before treatment（ P〈0. 01）,but that of the observation group was significantly lower than that of the control group（ P〈0. 01）. And the levels of hemorheology of both groups obviously decreased,but that of the observation group decreased more significantly,so difference was statistically significant（ P〈0. 01）. In addition,difference of incidence of drug adverse reactions before and after treatment was not statistically significant between groups（ P〉0. 05）. Conclusion The clinical effects of vinpocetine combined with Danhong injection are better than single vinpocetine for patients with acute cerebral infarction. Thus,it is worthy of promotion in clinical practice.