超声造影结合血清CA125在卵巢肿瘤定性诊断中的应用价值

Clinical Value of the Contrast-enhanced Ultrasonography Combined with Serum CA125 in the Qualitative Diagnosis of Ovarian Masses

目的探讨超声造影结合血清CA125在卵巢肿瘤定性诊断中的应用价值。方法回顾性分析经手术、病理证实的52例卵巢肿瘤的彩色多普勒表现、超声造影强化特点及血清CA125测定水平,并与病理结果进行对照,评价其诊断效能。结果彩色多普勒超声诊断卵巢肿瘤的灵敏性、特异性、诊断符合率分别为88.5%、84.6%、86.5%。超声造影结合血清CA125诊断卵巢肿瘤的灵敏性、特异性、诊断符合率分别为96.3%、96.0%、96.2%。Youden指数提示超声造影结合血清CA125的诊断效率高,二者具有统计学差异(0.731 vs 0.823,P<0.05)。超声造影结合血清CA125对卵巢肿瘤的定性诊断与病理结果的一致性较好(Kappa=0.9228)。结论实时超声造影显示卵巢肿瘤的血流灌注信息较彩色多普勒超声更具优势,结合血清CA125将显著提高卵巢肿瘤的早期诊断及鉴别诊断的准确性。

Objective To verify the clinical value of the contrast-enhanced ultrasonography（CEUS） combined with serum CA125 in the qualitative diagnosis of ovarian masses. Methods The findings of color Doppler, CEUS, and serum CA125 levels of 52 ovarian masses were retrospectively analyzed. The results were compared with pathological findings to evaluate its diagnosing effectiveness. Results The sensitivity, specificity, and accuracy in the diagnosis of benign and malignant ovarian masses were 88.5%, 84.6%, 86.5% with color Doppler, and 96.3%, 96.0%, 96.2% with CEUS combined with serum CA125 respectively. The Youden index indicated that CEUS combined with serum CA125 had better diagnosing effectiveness and the difference was statically significant（0.731 vs 0.823, P0.05）. CEUS combined with serum CA125 had good consistency with the pathological examination in the qualitative diagnosis of ovarian masses（Kappa=0.9228）. Conclusion The real-time contrast-enhanced ultrasonography has more advantages over color Doppler in demonstrating the blood vessel perfusion within ovarian tumors. When combined with detection of serum CA125, it can be used to improve the accuracy of early diagnosis of ovarian masses.