孕妇短PR间期与甲状腺激素水平的相关性分析

The relationship of short PR interval during pregnancy and the level of thyroid hormone

目的探讨女性孕期短PR间期的发生率、机制及与甲状腺激素水平的关系。方法采用今科心电信息网络系统工作站对40 301例健康体检者（其中女性未孕）及8 257例健康孕妇分别进行常规心电图检查,采用化学发光免疫测定法测定孕期游离三碘甲腺原氨酸（free three iodine thyroid original ammonia acid,FT3）,游离四碘甲腺原氨酸（free iodine thyroid original ammonia acid,FT4）,促甲状腺素（thyrotropin,TSH）。孕妇按孕周不同分孕早期（12周内）、孕中期（13～28周）和孕晚期（29周后）三组,分别进行PR间期及FT3、FT4、TSH的测定。结果健康体检者发生短PR间期120例（0.3%）,其中男41例（0.102%）,女79例（0.196%）;孕妇短PR间期111例（1.344%）,孕妇发生率明显增高,孕早中晚期的发生率两两比较,差异有统计学意义（P〈0.01）。FT3、FT4随孕周增加而降低,FT4在三组中两两比较,差异有统计学意义（P〈0.05）,TSH与孕周呈正相关,孕早中期比较差异无统计学意义（P〉0.05）,孕早中期与晚期比较差异有统计学意义（P〈0.05）。结论孕妇短PR间期发生率明显高于健康体检者,并与甲状腺激素水平有一定相关性。

Objective To investigate the characteristics and relationship of the incidence,mechanism and the level of thyroid hormone in the short PR interval during pregnancy. Methods the Jinke ECG network information system workstation to 40301 healthy non pregnant controls and p8257 cases of healthy pregnant women were routine ECG examination and by chemical luminescent immunoassay method and reagent of form a complete set to determine the free three iodine thyroid original ammonia acid（ FT3） during pregnancy and free iodine thyroid original ammonia acid（ FT4）,thyrotropin（ TSH）. The pregnant women were divided into groups according to different gestational age（ 12 weeks）,the middle gestational period（ 13-28 weeks）,three weeks after the second trimester（ 29 weeks）,and the data of,FT4,TSH,FT3,and PR were collected,and the results were statistically analyzed. Results 120 patients（ 0. 3%） had 79 cases（ 0. 196%）,41cases（ 0. 102%）,111 cases（ 1. 344%）,and two two cases,the incidence rate was significantly higher,the difference was statistically significant（ P〈0. 01）. FT3,FT4 increased with the increase of gestational age,FT4 in the two two groups,the difference was statistically significant（ P〈0. 05）,TSH increased with the increase of the gestational age,the difference was not statisticallysignificant（ P〈0. 05）,and the difference between early and late pregnancy was statistically significant（ P〈0. 05）. Conclusion the incidence of short PR interval in pregnant women was significantly higher than that of healthy non pregnant women.