血液WBC、hs-CRP和PCT联合检测在儿科肺炎患者中的临床应用

The Clinical Application of Children Pneumonia by Combined Detection of WBC, hs-CRP and PCT

目的探讨血液中白细胞(WBC)、超敏C-反应蛋白(hs-CRP)和降钙素原(PCT)联合检测在儿科肺炎患者中的应用价值。方法将150例儿科肺炎患儿分为细菌感染组和非细菌感染组,用Sysmex XS 800i血细胞分析仪检测全血WBC,用i-CHROMA免疫荧光分析仪检测血清hs-CRP水平,用mini-Vidas全自动致病菌快速检测仪检测血清PCT水平,并对结果进行分析。同时,选择60例健康儿童为健康对照组。结果治疗前,细菌感染组的血液WBC计数、hs-CRP水平和PCT水平均明显高于非细菌感染组和健康对照组,且差异具有统计学意义(P<0.05),而非细菌感染组和健康对照组的WBC、hs-CRP和PCT差异无统计学意义(P>0.05);治疗后,细菌感染组患者三个指标均明显下降,且治疗前后三个指标差异有统计学意义(P<0.05)。结论血液WBC、hs-CRP和PCT联合检测对儿科肺炎的早期诊断及预后判断有着重要的临床价值,且PCT特异性和敏感度均较高。

Objective To evaluate the clinical value of white blood cell（WBC）, hypersensitive C-reactive protein（hs-CRP） and procalcitonin（PCT） in children pneumonia. Methods The 150 children pneumonia cases were divided into bacterial infection group and non-bacterial infection group. The whole blood WBC was examined by Sysmex XS 800 i blood analyzer, serum hs-CRP level was examined by i-CHROMA immune fluorescence analyzer and serum PCT level was examined by mini-Vidas fast-detection apparatus for all automatic pathogenic bacteria. All the data were analyzed statistically, while 60 healthy children were taken as the control group.Results Before treatment, the WBC count, serum hs-CRP level and PCT level in bacterial infection group were significantly higher than those in non-bacterial infection group and control group（P 0.05）, and there was no significant difference in the three items above between non-bacterial infection group and control group（P0.05）.After treatment of antibiotics, the WBC, hs-CRP and PCT results showed a significant difference（P 0.05）.Conclusion The joint examination of WBC count, serum hs-CRP level and PCT level has important clinical value in the early diagnosis and the condition judgment of children with pneumonia. Of those, the PCT level has higher specificity and sensitivity.