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重视支气管热成形术治疗重度支气管哮喘的适宜人群及作用机制研究 被引量：16

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摘要 支气管哮喘（哮喘）是一种以可逆性气流受限为特征的常见呼吸系统疾病.全球有超过3亿哮喘患者,我国约有3 000万以上哮喘患者,其中约5％为重度哮喘,尽管应用了足量吸入性糖皮质激素和支气管舒张剂治疗仍难以有效控制哮喘症状,其急诊就医频率和住院频率分别为轻中度哮喘的15倍和20倍,是哮喘治疗费用增加和哮喘致残、致死的主要原因[1].
作者 林江涛 裘若帆
机构地区 中日友好医院呼吸与危重症医学科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2016年第3期161-163,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 北京市科委首都临床特色应用研究重点项目（2015-BKJ-001）
关键词 重度支气管哮喘 治疗费用 适宜人群 成形术 吸入性糖皮质激素 呼吸系统疾病 支气管舒张剂 哮喘患者
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献13

  • 1林江涛.努力提高我国难治性哮喘的防治和研究水平[J].中华结核和呼吸杂志,2010,33(8):561-562. 被引量：16
  • 2Brown RH, Wizeman W, Danek C, et al. In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography[J]. J Appl Physiol ( 1985 ), 2005, 98 (5) : 1603- 1606. DOI: 10. l152/japplphysiol. 01210. 2004.
  • 3Danek CJ, Lombard CM, Dungworth DL, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs[J]. J Appl Physiol (1985), 2004, 97 (5): 1946-1953. DOI: 10. l152/japplphysiol. 01282. 2003.
  • 4Cox PG, Miller J, Mitzner W, et al. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigation [ J ]. Eur Respir J, 2004, 24 ( 4 ) : 659- 663. DOI: 10. 1183/09031936.04. 00054604.
  • 5Cox G, Thomson N, Rubin AS, et al. Asthma control during theyear after bronchial thermoplasty[ J]. N Engl J Med, 2007, 356 (13) : 1327-1337. DOI : 10. 1056/NEJMoa064707.
  • 6苏楠.支气管热成形术的围手术期管理[J].中华结核和呼吸杂志,2015,38(12):883-885. 被引量：8
  • 7Pavord ID, Cox G, Thomson NC, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma[J]. Am J Respir Crit Care Med, 2007, 176 (12) : 1185-1191. DOI: 10. 1164/teem. 200704 -571.
  • 8OC. Castro M, Rubin A, Lavlolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma [J]. Am J Respir Crit Care Med, 2010, 181(2) :116-124. DOI: 10. 1164/rccm. 200903-0354OC.
  • 9Facciolongo N, Menzella F, Lusuardi M, et al. Recurrent lung atelectasis from fibrin plugs as a very early complication of bronchial thermoplasty: a case report [J]. Multidiscip Respir Med, 2015, 10(1) :9. DOI: 10. 1186/s40248-015-0002-7.
  • 10Balu A, Ryan D, Niven R. Lung abscess as a complication of bronchial thermoplasty [ J ]. J Asthma, 2015, 52 ( 7 ) : 740-742. DOI: 10.3109/02770903.2015. 1005844.

二级参考文献25

  • 1American Thoracic Society Workshop Report.Proceedings of the ATS workshop on refractory asthma:current understanding,recommendations,and unanswered questions.Am J Respir Crit Care Med,2000,162:2341-2351.
  • 2Chung KF,Godard P,Adelroth E,et al.Difficult/therapyresistant asthma:the need for an integrated approach to define clinical phenotypes,evaluate risk factors,understand pathophysiology and find novel therapies.ERS Task Force on Difficult/Therapy-Resistant Asthma.European Respiratory Society.Eur Respir J,1999,13:1198-1208.
  • 3ten Brinke A,Sterk PJ,Masclee AA,et al.Risk factors of frequent exacerbations in difficult-to-treat asthma.Eur Respir J,2005,26:812-818.
  • 4American Thoracic Society. Proceedings of the ATS workshop onrefractory asthma : current understanding,recommendations,andunanswered questions[ J]. Am J Respir Crit Care Med, 2000,162.6) :2341-2351.
  • 5ERS Task Force on Difficult/Therapy-Resistant Asthma, EuropeanRespiratory Society. Difficult/therapy-resistant asthma : the needfor an integrated approach to define clinical phenotypes,evaluaterisk factors,understand pathophysiology and find novel therapies[J]. Eur Respir J,1999,13(5) : 1198-1208.
  • 6Chung KF,Wenzel SE,Brozek JL,et al. International ERS/ATSguidelines on definition,evaluation and treatment of severe asthma[J].Eur Respir J, 2014, 43(2):343-373.
  • 7Lee JH, Haselkom T, Borish L, et al. Risk factors associatedwith persistent airflow limitation in severe or difficult-to-treatasthma : insights from the TENOR study [ J ]. Chest, 2007,132(6) : 1882-1889.
  • 8ten Brinke A, Sterk PJ, MascleeAA, et al. Risk factors offrequent exacerbations in difficult-to-treat asthma [ J ]. Eur RespirJ,2005, 26(5):812-818.
  • 9Silverman RA, Boudreaux ED, Woodruff PG, et al. Cigarettesmokingamong asthmatic adults presenting to 64 emergencydepartments[ J]. Chest,2003, 123(5) : 1472-1479.
  • 10Chung KF. New treatments for severe treatment-resistant asthma :targeting the right patient[ J]. Lancet Respir Med, 2013 ,1(8):639-652.

共引文献30

同被引文献123

引证文献16

二级引证文献236

中华结核和呼吸杂志
2016年 第3期

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