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支气管热成形术治疗支气管哮喘研究进展 被引量：11

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摘要 支气管热成形术（bronchial thermoplasty,BT）是一项新的具有较高安全性的支气管镜下治疗技术,具有显著减少气道平滑肌（airway smooth muscle,ASM）、降低ASM收缩力[1-5]、改善支气管哮喘（哮喘）控制、提高患者生活质量、减少药物使用等效果[6-9].我国于2014年正式批准将该技术用于治疗重症哮喘,其疗效与安全性正逐渐被越来越多的研究所证实[10-13].本文就BT在哮喘中的应用及其研究进展综述如下.
作者 裘若帆 林江涛
机构地区 中日友好医院呼吸与危重症医学科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2016年第3期213-217,共5页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 北京市科委首都临床特色应用研究重点项目（2015-BKJ-001）
关键词 支气管哮喘 镜下治疗 成形术 气道平滑肌 生活质量 重症哮喘 药物使用 进展综述
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献56

  • 1Danek C J, Lombard CM, Dungworth DL, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs[J]. J Appl Physiol(1985), 2004, 97(5) : 1946-1953. DOI: 10.1152/japplphysiol. 01282. 2003.
  • 2Brown RH, Wizeman W, Danek C, et al. Effect of bronchial thermoplasty on airway distensibility[ J]. Eur Respir J, 2005, 26 ( 2 ) : 277-282. DOI : 10.1183/09031936.05. 00006605.
  • 3Brown RH, Wizeman W, Danek C, et al. In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography[ J ]. J Appl Physiol ( 1985 ), 2005, 98 ( 5 ) : 1603- 1606. DOI: 10.1152/japplphysiol. 01210. 2004.
  • 4Cox PG, Miller J, Mitzner W, et al. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investjgation [ J ]. Eur Respir J, 2004, 24 ( 4 ) : 659- 663. DOI : 10.1183/09031936.04. 00054604.
  • 5Pretolani M, Dombret MC, Thabut G, et al. Reduction of airway smooth muscle mass by bronchial thermoplasty in patients with severe asthma[J]. Am J Respir Crit Care Med, 2014, 190(12) : 1452-1454. DOI : 10.1164/rccm. 201407-1374LE.
  • 6Cox G, Thomson N, Rubin AS, et al. Asthma control during the year after bronchial thermoplasty[ J]. N Engl J Med, 2007, 356 ( 13 ) : 1327-1337. DOI : 10. 1056/NEJMoa064707.
  • 7Thomson NC, Rubin AS, Niven RM, et al. Long-term(5year) safety of bronchial thermoplasty: asthma intervention research (AIR) trial[J]. BMC Pulmonary Med, 2011, 11:8. DOI: 10. 1186/1471-2466-11-8.
  • 8Castro M, Rubin A, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a muhicenter, randomized, double-blind, sham-controlled clinical trial[J]. Am J Respir Crit Care Med, 2010, 181(2) :116-124. DOI: 10. l164/rccm. 200903-0354OC.
  • 9Castro M, Rubin A, Laviolette M, et al. Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma[J]. Ann Allergy Asthma Immunol, 2011, 107 ( 1 ) :65- 70. DOI: 10. 1016/j. anai. 2011. 03. 005.
  • 10Stokes JR. Promising future therapies for asthma [ J ]. Int Immunopharmacol, 2014, 23 ( 1 ) :373-377. DOI: 10. 1016/j. intimp. 2014.05. 032.

二级参考文献58

  • 1Dolan CM, Fraher KE, Bleecker ER, et al. Design and baseline characteristics of the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma[ J]. Ann Allergy Asthma Immunol, 2004, 92(1 ):32-39.
  • 2Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma [J]. Eur Respir J, 2014, 43(2) :343-373.
  • 3Sutherland ER, Martin ILl, Bowler RP, et al. Physiologic correlates of distal lung inflammation in asthma[ J]. J Allergy Clin Immunol, 2004, 113(6) :1046-1050.
  • 4Berger P, Girodet PO, Begneret H, et al. Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis[ J]. FASEB J, 2003, 17 (14) :2139-2141.
  • 5Janssen LJ. Airway smooth muscle as a target in asthma and the beneficial effects of bronchial thermoplasty [ J ]. J Allergy (Cairo) , 2012, 2012:593784.
  • 6Mitzner W. Airway smooth muscle: the appendix of the lung[J]. Am J Respir Crit Care Med, 2004, 169(7) :787-790.
  • 7Miller JD, Cox G, Vincic L, et al. A prospective feasibility study of bronchial thermoplasty in the human airway[ J]. Chest, 2005, 127(6) :1999-2006.
  • 8Kaukel P, Herth FJ, Schuhmann M. Bronchial thermoplasty : interventional therapy in asthma[ J]. Ther Adv Respir Dis, 2014, 8(1) :22-29.
  • 9Cayetano KS, Chan AL, Albertson TE, et al. Bronchial thennoplasty: a new treatment paradigm for severe persistent asthma[ J ]. Clin Rev Allergy Immunol, 2012, 43 (1-2):184- 193.
  • 10Danek CJ, Lombard CM, Dungworth DL, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs[ J]. J Appl Physiol ( 1985 ) , 2004, 97 (5) : 1946-1953.

共引文献9

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引证文献11

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中华结核和呼吸杂志
2016年 第3期

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