摘要
目的探讨IL-17A基因多态性与自身免疫性疾病（autoimmune disease,AID）易感性的关系。方法计算机检索数据库,收集有关IL-17A基因多态性与AID易感性病例-对照研究,文献相关数据进行Meta分析,以病例组与对照组IL-17A基因多态性不同位点各种基因模型的比值比（OR）及95%CI为效应指标,并根据研究病种进行亚组分析。结果共14项研究符合纳入标准。Meta分析表明IL-17A rs2275913G/C多态性与AID易感性无明显相关性[AA vs GG：OR=0.963,95%CI：0.862~1.076,P=0.508;GA vs GG：OR=0.913,95%CI：0.741~1.126,P=0.395;GA/AA vs GG：OR=0.960,95%CI：0.868~1.062,P=0.431;AA vs GG/GA：OR=1.015,95%CI：0.916~1.124,P=0.781]。亚组分析表明IL-17A rs2275913G/C多态性与炎性肠疾病易感性无明显相关性。结论 IL-17A rs2275913G/C多态性与自身免疫性疾病无明显相关性。
Objective To explore the association between IL-17 A polymorphism and susceptibility of autoimmune disease（ AID）. Methods Data bases were comprehensively searched to retrace all the related studies on the associations between IL-17 A gene polymorphism and susceptibility of AID. The pooled odds ratios（ OR） with 95% confidence intervals（ 95% CI） of the association between IL-17 A polymorphism and susceptibility of AID were performed under different genetic model comparisons. Subgroup analysis was performed based on the type of diaesaes. Results Fourteen original studies were collected in the final data combination. The results of Meta-analysis showed that there were no significant associations between IL-17 A rs2275913G / C polymorphism and susceptibility of AID under different genetic models[AA vs GG： OR =0. 963,95% CI： 0. 862 ~1. 076,P =0. 508; GA vs GG： OR =0. 913,95% CI： 0. 741 ~ 1. 126,P =0. 395; GA / AA vs GG： OR = 0. 960,95 % CI： 0. 868 ~ 1. 062,P = 0. 431; AA vs GG / GA： OR = 1. 015,95%CI： 0. 916 ~ 1. 124,P = 0. 781]. Subgroup analysis showed that there was no significant association between IL-17 A rs2275913G / C polymorphism and susceptibility of inflammatory bowel disease. Conclusion Meta-analysis strongly suggests that there is no significant association between IL-17 A rs2275913G / C polymorphism and susceptibility of AID.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第3期326-329,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
湖北省卫生计委肝病专项基金资助项目(XF2012-7)
