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人尿源干细胞及其在骨组织工程中应用的研究进展 被引量:2

The application progress of human urine derived stem cells in bone tissue engineering
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摘要 骨组织工程领域已围绕种子细胞、支架材料、生长信息三个基础方向开展研究.干细胞是当前被广泛研究的种子细胞,从尿中分离得到的人尿源干细胞(hUSC)可贴壁生长,具有克隆性,可表达多数间充质干细胞标志物、外周细胞标志物,具备多分化潜能,经数代培养仍保持核型稳定,无成瘤性.hUSC获取途径无创且简便、培养体系稳定、具备多向分化潜能,有成为组织工程种子细胞新来源的潜力. The research of bone tissue engineering bases on three basic directions of seed cells,scaffold materials and growth information.Stem cells have been widely studied as seed cells.Human urinederived stem cell (hUSC) is extracted from urine and described to be adhesion growth,cloning,expression of the majority of mesenchymal stem cell markers and peripheral cell markers,multi-potential and no tumor but stable karyotype with passaging many times.Some researches proposed that hUSC might be a new source of seed cells in tissue engineering because of their invasive and convenient obtention,stable culture and multiple differentiation potential.
出处 《中华外科杂志》 CAS CSCD 北大核心 2016年第4期317-320,共4页 Chinese Journal of Surgery
关键词 干细胞 细胞分化 骨组织工程 Stem cells Cell differentiation Bone tissue engineering
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