电针结合补肾健脾方对老年骨质疏松患者骨密度及血钙和血清OPN水平的影响

The effect of electric acupuncture combined with Bushen Jianpi patients on bone mineral density,blood calcium and serum OPN levels of patients with osteoporosis

目的:探讨电针结合补肾健脾方对老年骨质疏松患者骨密度及血钙和血清OPN水平的影响。方法 :将原发性老年骨质疏松患者160例按随机数表法分为治疗组、电针组、中药组和西药组各40例。治疗组采用电针联合补肾健脾方治疗,电针组采用电针治疗,中药组采用补肾健脾方治疗,西药组口服骨化三醇软胶囊治疗,均连续治疗3个月。结果:治疗后四组的骨质疏松症症状分级的得分和血清OPN水平均较治疗前降低,骨密度和血钙则较治疗前升高(P<0.05)。与治疗组比较,电针组、中药组和西药组治疗后的各骨质疏松症症状分级的得分和血清OPN水平均升高,骨密度和血钙则降低(P<0.05)。与西药组比较,电针组和中药组治疗的各骨质疏松症症状分级的得分和血清OPN水平亦均降低,骨密度和血钙则升高(P<0.05)。四组治疗期间均无明显不良反应和并发症的发生。结论:电针结合补肾健脾方治疗老年骨质疏松可有效缓解患者的临床症状,降低血清OPN水平并提高其骨密度和血钙水平且副作用少,值得应用。

Objective：to investigate the impact of electric acupuncture combined with Bushen Jianpi prescription on bone mineral density,blood calcium and serum OPN levels of senile patients with osteoporosis.Methods：According to random number table method,160 senile patients with primary osteoporosis were divided into the joint group,electric acupuncture group,Chinese medicine group and western medicine group by random method,40 cases in each group.Joint group was treated by electric acupuncture combined with Bushen Jianpi prescription,electric acupuncture group was treated with electric acupuncture,traditional Chinese medicine group was treated with Bushen Jianpi prescription,and western medicine group was treated with calcitriol capsule,and all of the patients were continuously treated for 3 months.Results：Osteoporosis symptom score and serum OPN levels of 4groups after treatment were lower than that of before treatment,while bone mineral density and blood calcium level were higher than that of before treatment（P 〈0.05）.Compared with joint group,osteoporosis symptom score and serum OPN levels of electric acupuncture group,Chinese medicine group and western medicine group after treatment were elevated,while bone mineral density and blood calcium level were leveled down（P 〈0.05）.Compared with western medicine group,osteoporosis symptom score and serum OPN levels of electric acupuncture group and Chinese medicine treatment were leveled down while bone mineral density and blood calcium level were elevated（P 〈0.05）.All of the 4groups had no obvious adverse reaction and complications during treatment.Conclusion：Electric acupuncture combined with invigorating kidney and strengthening spleen prescription treating senile osteoporosis can effectively alleviate clinical symptoms,reduce the serum OPN levels and improve bone mineral density and blood calcium levels without side effects.so it is worthy of clinical spromotion and usage.