痰热清注射液联合十宣放血对慢性阻塞性肺疾病合并肺部感染患者CRP、IL-1、TNF-α的影响

Effects of Tanreqing Injection combined with Blood-letting Therapy of Ten Xuan Points(EX-UE11) on CRP, IL-1, TNF-α in Patients with Chronic Obstructive Pulmonary Disease complicated with Pulmonary Infection

目的:探讨痰热清注射液联合十宣放血对慢性阻塞性肺疾病(COPD)合并肺部感染患者CRP、IL-1、TNF-α的影响。方法:选取96例COPD合并肺部感染患者,随机分为对照组和治疗组,每组48例。对照组予西医对症治疗,治疗组在对照组基础上予痰热清注射液联合十宣放血治疗。观察两组治疗前后CRP、IL-1、TNF-α的变化,并评价不良反应及临床疗效。结果:两组治疗后CRP、IL-1、TNF-α均低于治疗前(P<0.05);治疗组治疗后CRP、IL-1、TNF-α均低于对照组(P<0.05)。治疗组总不良反应发生率(6.3%)低于对照组(20.8%),差异有统计学意义(P<0.05)。治疗组总有效率(97.9%)优于对照组(85.4%),差异有统计学意义(P<0.05)。结论:痰热清注射液联合十宣放血疗法能有效降低慢性阻塞性肺疾病合并肺部感染患者血清CRP、IL-1、TNF-α,提高临床疗效。

Objective： To investigate the effects of Tanreqing（痰热清） injection combined with blood-letting therapy of ten xuan points （EX-UEll） on CRP, IL-1, TNF-αin patients with chronic obstructive pulmonary dis- ease complicated with pulmonary infection. Methods： The 96 patients with chronic obstructive pulmonary disease complicated with pulmonary infection were randomly divided into control group and treatment group, each group of 48 cases. The control group received the western medicine symptomatic treatment, and the treatment group was treated with ten xuan bloodletting therapy on the basis of control group. The CRP, IL-1, the changes of TNF-α, adverse reactions and clinical curative effects were observed. Results： The content of CRP, TNF-α, IL- 1 in two groups both decreased after treatment （P〈0.05）, and the treatment group was lower than the control group （P〈0.05）. The incidence rate of adverse drug reactions of the treatment group was 6.3%, and the control group was 20.8% （P〈0.05）. The total effective rate of the treatment group was 97.9%, and the control group was 85.4% （P〈0.05）. Conclusion： Tanreqing injection combined with blood-letting therapy of ten xuan points （EX- UEll） can decrease the content of CRP, IL-1, TNF-ain patients with chronic obstructive pulmonary disease complicated with pulmonary infection, and improve the clinical curative effect.